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Nano/micro-scale magnetophoretic devices for biomedical applications

Title
Nano/micro-scale magnetophoretic devices for biomedical applications
Authors
Lim, B[Lim, Byeonghwa]Vavassori, P[Vavassori, Paolo]Sooryakumar, R[Sooryakumar, R.]Kim, C[Kim, CheolGi]
DGIST Authors
Lim, B[Lim, Byeonghwa]; Kim, C[Kim, CheolGi]
Issue Date
2017-01-25
Citation
Journal of Physics D: Applied Physics, 50(3)
Type
Article
Article Type
Review
Keywords
BioassayBiochipsBiomedical ApplicationsCell SortingDomain WallsIntegrated EngineeringMagnetic Domain WallsMagnetic DomainsMagnetic Field GradientMagnetic StructureMagnetismMagnetophoresisMagnetsMedical ApplicationsMicro/NanopatternsMicroarraysMolecular BiologyRemote ControlRemote ManipulationSingle-Cell Manipulation
ISSN
0022-3727
Abstract
In recent years there have been tremendous advances in the versatility of magnetic shuttle technology using nano/micro-scale magnets for digital magnetophoresis. While the technology has been used for a wide variety of single-cell manipulation tasks such as selection, capture, transport, encapsulation, transfection, or lysing of magnetically labeled and unlabeled cells, it has also expanded to include parallel actuation and study of multiple bio-entities. The use of nano/micro-patterned magnetic structures that enable remote control of the applied forces has greatly facilitated integration of the technology with microfluidics, thereby fostering applications in the biomedical arena. The basic design and fabrication of various scaled magnets for remote manipulation of individual and multiple beads/cells, and their associated energies and forces that underlie the broad functionalities of this approach, are presented. One of the most useful features enabled by such advanced integrated engineering is the capacity to remotely tune the magnetic field gradient and energy landscape, permitting such multipurpose shuttles to be implemented within lab-on-chip platforms for a wide range of applications at the intersection of cellular biology and biotechnology. © 2016 IOP Publishing Ltd.
URI
http://hdl.handle.net/20.500.11750/2045
DOI
10.1088/1361-6463/50/3/033002
Publisher
Institute of Physics Publishing
Files:
There are no files associated with this item.
Collection:
Emerging Materials ScienceETC1. Journal Articles


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