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The anatomy of mammalian sweet taste receptors

Title
The anatomy of mammalian sweet taste receptors
Authors
Chéron, J.-B.[Chéron, Jean Baptiste]Golebiowski, J.[Golebiowski, Jérôme]Antonczak, S.[Antonczak, Serge]Fiorucci, S.[Fiorucci, Sébastien]
DGIST Authors
Golebiowski, J.[Golebiowski, Jérôme]
Issue Date
2017
Citation
Proteins: Structure, Function and Bioinformatics, 85(2), 332-341
Type
Article
Article Type
Article
Keywords
Chemical SensesClass CGPCRStructure-Function RelationshipsSweet TasteT1R
ISSN
0887-3585
Abstract
All sweet-tasting compounds are detected by a single G-protein coupled receptor (GPCR), the heterodimer T1R2-T1R3, for which no experimental structure is available. The sweet taste receptor is a class C GPCR, and the recently published crystallographic structures of metabotropic glutamate receptor (mGluR) 1 and 5 provide a significant step forward for understanding structure-function relationships within this family. In this article, we recapitulate more than 600 single point site-directed mutations and available structural data to obtain a critical alignment of the sweet taste receptor sequences with respect to other class C GPCRs. Using this alignment, a homology 3D-model of the human sweet taste receptor is built and analyzed to dissect out the role of key residues involved in ligand binding and those responsible for receptor activation. Proteins 2017; 85:332–341. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
URI
http://hdl.handle.net/20.500.11750/2093
DOI
10.1002/prot.25228
Publisher
John Wiley and Sons Inc.
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesETC1. Journal Articles


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