Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Sims, Jennie R. | - |
dc.contributor.author | Ow, Maria C. | - |
dc.contributor.author | Nishiguchi, Mailyn A. | - |
dc.contributor.author | Kim, Kyuhyung | - |
dc.contributor.author | Sengupta, Piali | - |
dc.contributor.author | Hall, Sarah E. | - |
dc.date.available | 2017-07-05T08:38:11Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2016-06 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2257 | - |
dc.description.abstract | Environmental stress during early development can impact adult phenotypes via programmed changes in gene expression. C. elegans larvae respond to environmental stress by entering the stress-resistant dauer diapause pathway and resume development once conditions improve (postdauers). Here we show that the osm-9 TRPV channel gene is a target of developmental programming and is down-regulated specifically in the ADL chemosensory neurons of postdauer adults, resulting in a corresponding altered olfactory behavior that is mediated by ADL in an OSM-9-dependent manner. We identify a cis-acting motif bound by the DAF-3 SMAD and ZFP-1 (AF10) proteins that is necessary for the differential regulation of osm-9, and demonstrate that both chromatin remodeling and endo-siRNA pathways are major contributors to the transcriptional silencing of the osm-9 locus. This work describes an elegant mechanism by which developmental experience influences adult phenotypes by establishing and maintaining transcriptional changes via RNAi and chromatin remodeling pathways. | - |
dc.publisher | eLife Sciences Publications Ltd. | - |
dc.title | Developmental programming modulates olfactory behavior in C. elegans via endogenous RNAi pathways | - |
dc.type | Article | - |
dc.identifier.doi | 10.7554/eLife.11642.001 | - |
dc.identifier.scopusid | 2-s2.0-84978858519 | - |
dc.identifier.bibliographicCitation | eLife, v.5 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordPlus | Animal Cell | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | Caenorhabditis Elegans | - |
dc.subject.keywordPlus | CHILDHOOD ABUSE | - |
dc.subject.keywordPlus | Chromatin Assembly and Disassembly | - |
dc.subject.keywordPlus | Controlled Study | - |
dc.subject.keywordPlus | CONTROLLING DAUER FORMATION | - |
dc.subject.keywordPlus | DOUBLE-STRANDED-RNA | - |
dc.subject.keywordPlus | Down Regulation | - |
dc.subject.keywordPlus | EPIGENETIC REGULATION | - |
dc.subject.keywordPlus | Fluorescence in Situ Hybridization | - |
dc.subject.keywordPlus | Gene Expression | - |
dc.subject.keywordPlus | GLUCOCORTICOID-RECEPTOR | - |
dc.subject.keywordPlus | Immunoprecipitation | - |
dc.subject.keywordPlus | LARVAL DEVELOPMENT | - |
dc.subject.keywordPlus | Mutagenesis | - |
dc.subject.keywordPlus | NemATODE CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | Neurons | - |
dc.subject.keywordPlus | Nonhuman | - |
dc.subject.keywordPlus | Polymerase Chain Reaction | - |
dc.subject.keywordPlus | Protein Expression | - |
dc.subject.keywordPlus | RECEPTor GENE-EXPRESSION | - |
dc.subject.keywordPlus | RNA Interference | - |
dc.subject.keywordPlus | Smelling | - |
dc.subject.keywordPlus | Transforming Growth Factor Beta | - |
dc.subject.keywordPlus | WILD-TYPE | - |
dc.subject.keywordPlus | Zinc Finger Protein | - |
dc.citation.title | eLife | - |
dc.citation.volume | 5 | - |