Cited 3 time in webofscience Cited 3 time in scopus

Sugary interfaces mitigate contact damage where stiff meets soft

Title
Sugary interfaces mitigate contact damage where stiff meets soft
Authors
Yoo, HY[Yoo, Hee Young]Iordachescu, M[Iordachescu, Mihaela]Huang, J[Huang, Jun]Hennebert, E[Hennebert, Elise]Kim, S[Kim, Sangsik]Rho, S[Rho, Sangchul]Foo, M[Foo, Mathias]Flammang, P[Flammang, Patrick]Zeng, HB[Zeng, Hongbo]Hwang, D[Hwang, Daehee]Waite, JH[Waite, J. Herbert]Hwang, DS[Hwang, Dong Soo]
DGIST Authors
Hwang, D[Hwang, Daehee]
Issue Date
2016-06
Citation
Nature Communications, 7
Type
Article
Article Type
Article
Keywords
Animal ExperimentAtrinaAtrina PectinataAtrina Pectinata Foot Protein 1BivalveCell MembraneCells and Cell ComponentsControlled StudyDOPAEquipmentFerric IonImaging MethodImmune ResponseImmunoassayImmunochemistryMannoseMusselNon-HumanNucleotide SequenceProteinProtein LocalizationRaman SpectrometryShellSoft TissueSugarUnclassified Drug
ISSN
2041-1723
Abstract
The byssal threads of the fan shell Atrina pectinata are non-living functional materials intimately associated with living tissue, which provide an intriguing paradigm of bionic interface for robust load-bearing device. An interfacial load-bearing protein (A. pectinata foot protein-1, apfp-1) with L-3,4-dihydroxyphenylalanine (DOPA)-containing and mannose-binding domains has been characterized from Atrina's foot. apfp-1 was localized at the interface between stiff byssus and the soft tissue by immunochemical staining and confocal Raman imaging, implying that apfp-1 is an interfacial linker between the byssus and soft tissue, that is, the DOPA-containing domain interacts with itself and other byssal proteins via Fe3 + -DOPA complexes, and the mannose-binding domain interacts with the soft tissue and cell membranes. Both DOPA- and sugar-mediated bindings are reversible and robust under wet conditions. This work shows the combination of DOPA and sugar chemistry at asymmetric interfaces is unprecedented and highly relevant to bionic interface design for tissue engineering and bionic devices.
URI
http://hdl.handle.net/20.500.11750/2275
DOI
10.1038/ncomms11923
Publisher
Nature Publishing Group
Related Researcher
  • Author Hwang, Dae Hee Systems Biology and Medicine Lab
  • Research Interests Multilayered spatiotemporal networks; Regulatory motifs or pathways; Metabolite-protein networks; Network stochasticity; Proteomics and informatics
Files:
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Collection:
New BiologyETC1. Journal Articles


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