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Sugary interfaces mitigate contact damage where stiff meets soft
- Sugary interfaces mitigate contact damage where stiff meets soft
- Yoo, HY[Yoo, Hee Young]; Iordachescu, M[Iordachescu, Mihaela]; Huang, J[Huang, Jun]; Hennebert, E[Hennebert, Elise]; Kim, S[Kim, Sangsik]; Rho, S[Rho, Sangchul]; Foo, M[Foo, Mathias]; Flammang, P[Flammang, Patrick]; Zeng, HB[Zeng, Hongbo]; Hwang, D[Hwang, Daehee]; Waite, JH[Waite, J. Herbert]; Hwang, DS[Hwang, Dong Soo]
- DGIST Authors
- Hwang, D[Hwang, Daehee]
- Issue Date
- Nature Communications, 7
- Article Type
- Animal Experiment; Atrina; Atrina Pectinata; Atrina Pectinata Foot Protein 1; Bivalve; Cell Membrane; Cells and Cell Components; Controlled Study; DOPA; Equipment; Ferric Ion; Imaging Method; Immune Response; Immunoassay; Immunochemistry; Mannose; Mussel; Non-Human; Nucleotide Sequence; Protein; Protein Localization; Raman Spectrometry; Shell; Soft Tissue; Sugar; Unclassified Drug
- The byssal threads of the fan shell Atrina pectinata are non-living functional materials intimately associated with living tissue, which provide an intriguing paradigm of bionic interface for robust load-bearing device. An interfacial load-bearing protein (A. pectinata foot protein-1, apfp-1) with L-3,4-dihydroxyphenylalanine (DOPA)-containing and mannose-binding domains has been characterized from Atrina's foot. apfp-1 was localized at the interface between stiff byssus and the soft tissue by immunochemical staining and confocal Raman imaging, implying that apfp-1 is an interfacial linker between the byssus and soft tissue, that is, the DOPA-containing domain interacts with itself and other byssal proteins via Fe3 + -DOPA complexes, and the mannose-binding domain interacts with the soft tissue and cell membranes. Both DOPA- and sugar-mediated bindings are reversible and robust under wet conditions. This work shows the combination of DOPA and sugar chemistry at asymmetric interfaces is unprecedented and highly relevant to bionic interface design for tissue engineering and bionic devices.
- Nature Publishing Group
- Related Researcher
Hwang, Dae Hee
Systems Biology and Medicine Lab
Multilayered spatiotemporal networks; Regulatory motifs or pathways; Metabolite-protein networks; Network stochasticity; Proteomics and informatics
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