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The effect of neutral-surface iron oxide nanopar-ticles on cellular uptake and signaling pathways

Title
The effect of neutral-surface iron oxide nanopar-ticles on cellular uptake and signaling pathways
Authors
Kim, E[Kim, Eunjoo]Kim, JM[Kim, Joon Mee]Kim, L[Kim, Lucia]Choi, SJ[Choi, Suk Jin]Park, IS[Park, In Suh]Han, JY[Han, Jee Young]Chu, YC[Chu, Young Chae]Choi, ES[Choi, Eun Sook]Na, K[Na, Kun]Hong, SS[Hong, Soon-Sun]
DGIST Authors
Kim, E[Kim, Eunjoo]; Choi, ES[Choi, Eun Sook]
Issue Date
2016
Citation
International Journal of Nanomedicine, 11, 4595-4607
Type
Article
Article Type
Article
Keywords
3-MethacryloxypropyltrimethoxysilaneAccumulationAnimalAnimalsCell DeathCell LineChemistryDextranDextransEndocytosisEndothelial CellsEndothelium CellFerric CompoundsFerric IonFerric OxideGene Expression ProfilingHumanHumansInfrared SpectroscopyIronIron Oxide NanoparticlesMagnetite NanoparticleMagnetite NanoparticlesMetabolismMethacrylatesMethacrylic Acid DerivativeNanoparticleNanoparticlesNeutral Hydrophobic SurfaceRats, Sprague-DawleyReactive Oxygen MetaboliteReactive Oxygen Species (ROS)Signal TransductionSignaling PathwaySilane DerivativeSilanesSpectroscopy, Fourier Transform InfraredSprague Dawley RatSuperparamagnetic Iron OxideTissue DistributionUltrastructureUptake
ISSN
1178-2013
Abstract
In recent years, iron oxide nanoparticles (IONPs) have been applied widely to biomedical fields. However, the relationship between the physicochemical properties of IONPs and their biological behavior is not fully understood yet. We prepared 3-methacryl-oxypropyltrimethoxysilane (MPS)-coated IONPs, which have a neutral hydrophobic surface, and compared their biological behavior to that of Resovist (ferucarbotran), a commercialized IONP formulation modified with carboxymethyl dextran. The rate of MPS-IONP uptake by human aortic endothelial cells (HAoECs) was higher than ferucarbotran uptake, indicating that the neutral hydrophobic nature of MPS-IONPs allowed them to be absorbed more readily through the plasma membrane. However, the signaling pathways activated by MPS-IONPs and ferucarbotran were comparable, suggesting that surface charge is not a key factor for inducing changes in HAoECs. In vivo fate analysis showed that MPS-IONPs accumulated for longer periods in tissues than hydrophilic ferucarbotran. These findings could enlarge our understanding of NP behavior for advanced applications in the biomedical field.
URI
http://hdl.handle.net/20.500.11750/2308
DOI
10.2147/IJN.S110332
Publisher
Dove Medical Press
Related Researcher
Files:
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Collection:
Companion Diagnostics and Medical Technology Research Group1. Journal Articles


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