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SREBP and MDT-15 protect C. elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat

Title
SREBP and MDT-15 protect C. elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat
Authors
Lee, D[Lee, Dongyeop]Jeong, DE[Jeong, Dae-Eun]Son, HG[Son, Heehwa G.]Yamaoka, Y[Yamaoka, Yasuyo]Kim, H[Kim, Hyunmin]Seo, K[Seo, Keunhee]Khan, AA[Khan, Abdul Aziz]Roh, TY[Roh, Tae-Young]Moon, DW[Moon, Dae Won]Lee, Y[Lee, Youngsook]Lee, SJV[Lee, Seung-Jae V.]
DGIST Authors
Kim, H[Kim, Hyunmin]; Moon, DW[Moon, Dae Won]
Issue Date
2015-12-01
Citation
Genes and Development, 29(23), 2490-2503
Type
Article
Article Type
Article
Keywords
AgingC. ElegansCaenorhabditis ElegansControlled StudyEndocytosisFatGenetic ScreeningGlucoseGlucose IntakeGlucotoxicityGlycolysisLifespanMDT-15MetaboliteNon-HumanPriority JournalSaturated Fatty AcidSREBPSterol Regulatory Element Binding ProteinTranscription FactorTranscription Factor MDT15Unclassified DrugUnsaturated Fatty AcidUpregulation
ISSN
0890-9369
Abstract
Glucose-rich diets shorten the life spans of various organisms. However, the metabolic processes involved in this phenomenon remain unknown. Here, we show that sterol regulatory element-binding protein (SREBP) and mediator- 15 (MDT-15) prevent the life-shortening effects of a glucose-rich diet by regulating fat-converting processes in Caenorhabditis elegans. Up-regulation of the SREBP/MDT-15 transcription factor complex was necessary and sufficient for alleviating the life-shortening effect of a glucose-rich diet. Glucose feeding induced key enzymes that convert saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), which are regulated by SREBP and MDT-15. Furthermore, SREBP/MDT-15 reduced the levels of SFAs and moderated glucose toxicity on life span. Our study may help to develop strategies against elevated blood glucose and free fatty acids, which cause glucolipotoxicity in diabetic patients. © 2015 Lee et al.
URI
http://hdl.handle.net/20.500.11750/2317
DOI
10.1101/gad.266304.115
Publisher
Cold Spring Harbor Laboratory Press
Files:
There are no files associated with this item.
Collection:
New BiologyNanoBio Imaging Laboratory1. Journal Articles
New BiologyETC1. Journal Articles


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