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Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64

Title
Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64
Authors
Bhatt, N[Bhatt, Nikunj]Soni, N[Soni, Nisarg]Ha, YS[Ha, Yeong Su]Lee, W[Lee, Woonghee]Pandya, DN[Pandya, Darpan N.]Sarkar, S[Sarkar, Swarbhanu]Kim, JY[Kim, Jung Young]Lee, H[Lee, Hochun]Kim, SH[Kim, Sun Hee]An, GI[An, Gwang Il]Yoo, J[Yoo, Jeongsoo]
DGIST Authors
Lee, H[Lee, Hochun]
Issue Date
2015-11
Citation
ACS Medicinal Chemistry Letters, 6(11), 1162-1166
Type
Article
Article Type
Article
Keywords
Bi-Functional ChelatorChelating AgentCopperCopper 64Copper ComplexCyclic PotentiometryDrug SynthesisElectron Spin ResonanceHigh Performance Liquid ChromatographyIon Exchange ChromatographyParaformaldehydePhosphonate Pendant ArmsPhosphonic Acid DerivativePriority JournalPropylenePropylene Cross BridgeRadiopharmaceuticals
ISSN
1948-5875
Abstract
A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, 64Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A). © 2015 American Chemical Society.
URI
http://hdl.handle.net/20.500.11750/2324
DOI
10.1021/acsmedchemlett.5b00362
Publisher
American Chemical Society
Related Researcher
  • Author Lee, Ho Chun Electrochemistry Laboratory for Sustainable Energy(ELSE)
  • Research Interests Lithium-ion batteries; Novel Materials for rechargeable batteries; Novel energy conversion;storage systems; Electrochemistry; 리튬이차전지; 이차전지용 신규 전극 및 전해액; 신규 에너지변환 및 저장 시스템; 전기화학
Files:
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Collection:
Energy Science and EngineeringElectrochemistry Laboratory for Sustainable Energy(ELSE)1. Journal Articles


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