Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Hwajeong | - |
dc.contributor.author | Park, Sung Soo | - |
dc.contributor.author | Seo, Jooyeok | - |
dc.contributor.author | Ha, Chang-Sik | - |
dc.contributor.author | Moon, Cheil | - |
dc.contributor.author | Kim, Youngkyoo | - |
dc.date.available | 2017-07-05T08:55:59Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2422 | - |
dc.description.abstract | Here we shortly report a protein device platform that is extremely stable in a buffer condition similar to human bodies. The protein device platform was fabricated by covalently attaching cytochrome c (cyt c) protein molecules to organic coupler molecules (pyridine dicarboxylic acid, PDA) that were already covalently bound to an electron-transporting substrate. A cubic nanostructured mesoporous titania film was chosen as an electron-transporting substrate because of its large-sized cubic holes (∼7 nm) and highly crystalline cubic titania walls (∼0.4 nm lattice). Binding of PDA molecules to the mesoporous titania surface was achieved by esterification reaction between carboxylic acid groups (PDA) and hydroxyl groups (titania) in the presence of 1-ethyl-3-(3- dimethylaminopropyl) carbodiimide (EDC) mediator, whereas the immobilization of cyt c to the PDA coupler was carried out by the EDC-mediated amidation reaction between carboxylic acid groups (PDA) and amine groups (cyt c). Results showed that the 2,4-position isomer among several PDAs exhibited the highest oxidation and reduction peak currents. The cyt c-immobilized PDA-bound titania substrates showed stable and durable electrochemical performances upon continuous current-voltage cycling for 240 times (the final current change was less than 3%) and could detect superoxide that is a core indicator for various diseases including cancers. © 2013 American Chemical Society. | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.title | Stable Protein Device Platform Based on Pyridine Dicarboxylic Acid-Bound Cubic-Nanostructured Mesoporous Titania Films | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/am401850n | - |
dc.identifier.scopusid | 2-s2.0-84882790007 | - |
dc.identifier.bibliographicCitation | ACS Applied Materials & Interfaces, v.5, no.15, pp.6873 - 6878 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordAuthor | protein device | - |
dc.subject.keywordAuthor | cytochrome c | - |
dc.subject.keywordAuthor | mesoporous titania | - |
dc.subject.keywordAuthor | organic coupler | - |
dc.subject.keywordAuthor | stability | - |
dc.subject.keywordAuthor | superoxide | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | ELECTRON | - |
dc.subject.keywordPlus | SUPEROXIDE | - |
dc.citation.endPage | 6878 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 6873 | - |
dc.citation.title | ACS Applied Materials & Interfaces | - |
dc.citation.volume | 5 | - |
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