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Solid-state and solvent-free synthesis of azines, pyrazoles, and pyridazinones using solid hydrazine

Title
Solid-state and solvent-free synthesis of azines, pyrazoles, and pyridazinones using solid hydrazine
Authors
Lee, B[Lee, Byeongno]Kang, P[Kang, Philjun]Lee, KH[Lee, Kyu Hyung]Cho, J[Cho, Jaeheung]Nam, W[Nam, Wonwoo]Lee, WK[Lee, Won Koo]Hur, NH[Hur, Nam Hwi]
DGIST Authors
Cho, J[Cho, Jaeheung]
Issue Date
2013-03-13
Citation
Tetrahedron Letters, 54(11), 1384-1388
Type
Article
Article Type
Article
Keywords
1,2 Dicarbonyl DerivativeAzine DerivativeAzinesCarbon DioxideCatalystChemical StructureFunctional GroupHydrazinePyrazole DerivativePyrazolesPyridazinone DerivativePyridazinonesSolid StateSolid State ReactionSolventSolvent-Free ConditionsSynthesisUnclassified DrugWater
ISSN
0040-4039
Abstract
Azines, pyrazoles, and pyridazinones were isolated as the sole products in high yields (>97%) by grinding solid hydrazine (H3N +NHCO2 -) with di-carbonyl compounds or by their reaction in the absence of solvent. Neither catalysts nor additives were needed to promote the reactions. The solid-state and solvent-free reactions proceeded under ambient conditions and did not produce any wastes other than water and carbon dioxide. They are operationally easy, environmentally safe, and readily scalable, allowing for highly selective synthesis of compounds containing the hydrazine motif. Copyright© 2012 Published by Elsevier Ltd.
URI
http://hdl.handle.net/20.500.11750/2437
DOI
10.1016/j.tetlet.2012.12.106
Publisher
Elsevier Ltd
Files:
There are no files associated with this item.
Collection:
Emerging Materials ScienceETC1. Journal Articles


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