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Optogenetic and chemogenetic approaches for studying astrocytes and gliotransmitters

Title
Optogenetic and chemogenetic approaches for studying astrocytes and gliotransmitters
Authors
Bang, J.[Bang, Ju Won]Kim, H.Y.[Kim, Hak Yeong]Lee, H.[Lee, Hyo Sang]
DGIST Authors
Bang, J.[Bang, Ju Won]; Kim, H.Y.[Kim, Hak Yeong]; Lee, H.[Lee, Hyo Sang]
Issue Date
2016
Citation
Experimental Neurobiology, 25(5), 205-221
Type
Article
Article Type
Review
Keywords
AstrocytesChannelrhodopsinChemogeneticsDREADDGliotransmitterOptogenetics
ISSN
1226-2560
Abstract
The brain consists of heterogeneous populations of neuronal and non-neuronal cells. The revelation of their connections and interactions is fundamental to understanding normal brain functions as well as abnormal changes in pathological conditions. Optogenetics and chemogenetics have been developed to allow functional manipulations both in vitro and in vivo to examine causal relationships between cellular changes and functional outcomes. These techniques are based on genetically encoded effector molecules that respond exclusively to exogenous stimuli, such as a certain wavelength of light or a synthetic ligand. Activation of effector molecules provokes diverse intracellular changes, such as an influx or efflux of ions, depolarization or hyperpolarization of membranes, and activation of intracellular signaling cascades. Optogenetics and chemogenetics have been applied mainly to the study of neuronal circuits, but their use in studying non-neuronal cells has been gradually increasing. Here we introduce recent studies that have employed optogenetics and chemogenetics to reveal the function of astrocytes and gliotransmitter. © Experimental Neurobiology 2016.
URI
http://hdl.handle.net/20.500.11750/2751
DOI
10.5607/en.2016.25.5.205
Publisher
Korean Society for Neurodegenerative Disease
Related Researcher
  • Author Lee, Hyo Sang Laboratory of Affective Neuroscience
  • Research Interests Neuronal circuit mechanisms underlying emotional behaviors; 정서적 행동을 매개하는 신경회로 연구
Files:
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Collection:
Brain and Cognitive SciencesLaboratory of Affective Neuroscience1. Journal Articles


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