Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Yoo, Seung Jun | - |
dc.contributor.author | Cho, Bongki | - |
dc.contributor.author | Moon, Chanil | - |
dc.contributor.author | Yu, Seong-Woon | - |
dc.contributor.author | Moon, Cheil | - |
dc.date.available | 2017-07-11T05:38:59Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.citation | CNS and Neurological Disorders - Drug Targets, v.15, no.8, pp.927 - 934 | - |
dc.identifier.issn | 1871-5273 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2768 | - |
dc.description.abstract | Erythropoietin (EPO) has been shown to be a key cytokine in the production of erythrocytes from erythroblasts. Recently, attempts have been made to adopt EPO as a drug target for neuroprotection in selected neurological pathologies. In the current study, a novel EPO-derived peptide which mimics the weak binding site of EPO to its receptor (MK-X) was generated. Experimental results demonstrated that MK-X was able to ameliorate neuronal death due to reactive oxygen species and conditions of oxidative stress similar to EPO. In addition, MK-X induced long-lasting Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) and Akt activation. Furthermore, treatment with inhibitors of ERK1/2 and Akt abolished the neuroprotective effect of MK-X. Unlike EPO, however, MK-X did not induce cellular proliferation. Collectively, the results of the current study suggested that MK-X may be useful as a novel neuroprotective reagent. © 2016 Bentham Science Publishers. | - |
dc.language | English | - |
dc.publisher | Bentham Science Publishers | - |
dc.title | Neuroprotective Effects of an Erythropoietin-Derived Peptide in PC12 Cells under Oxidative Stress | - |
dc.type | Article | - |
dc.identifier.doi | 10.2174/1871527315666160813223329 | - |
dc.identifier.wosid | 000387121800008 | - |
dc.identifier.scopusid | 2-s2.0-84989227719 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | CNS and Neurological Disorders - Drug Targets | - |
dc.contributor.nonIdAuthor | Yoo, Seung Jun | - |
dc.contributor.nonIdAuthor | Moon, Chanil | - |
dc.identifier.citationVolume | 15 | - |
dc.identifier.citationNumber | 8 | - |
dc.identifier.citationStartPage | 927 | - |
dc.identifier.citationEndPage | 934 | - |
dc.identifier.citationTitle | CNS and Neurological Disorders - Drug Targets | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Erythropoietin receptor | - |
dc.subject.keywordAuthor | erythropoietin | - |
dc.subject.keywordAuthor | neuronal death | - |
dc.subject.keywordAuthor | peptide | - |
dc.subject.keywordAuthor | proliferation | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordPlus | AGONIST | - |
dc.subject.keywordPlus | ANemIA | - |
dc.subject.keywordPlus | BETA-CHAIN | - |
dc.subject.keywordPlus | Cytokine | - |
dc.subject.keywordPlus | EPO RECEPTOR | - |
dc.subject.keywordPlus | Erythropoietin | - |
dc.subject.keywordPlus | Erythropoietin | - |
dc.subject.keywordPlus | Erythropoietin Receptor | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | Neuronal Death | - |
dc.subject.keywordPlus | Neuronal Death | - |
dc.subject.keywordPlus | Peptide | - |
dc.subject.keywordPlus | Peptide | - |
dc.subject.keywordPlus | Proliferation | - |
dc.subject.keywordPlus | Proliferation | - |
dc.subject.keywordPlus | Proliferation | - |
dc.subject.keywordPlus | Reactive Oxygen Species | - |
dc.subject.keywordPlus | Reactive Oxygen Species | - |
dc.subject.keywordPlus | TISSUE PROTECTION | - |
dc.contributor.affiliatedAuthor | Yoo, Seung Jun | - |
dc.contributor.affiliatedAuthor | Cho, Bongki | - |
dc.contributor.affiliatedAuthor | Moon, Chanil | - |
dc.contributor.affiliatedAuthor | Yu, Seong-Woon | - |
dc.contributor.affiliatedAuthor | Moon, Cheil | - |
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