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Establishment of a mouse model for pulmonary inflammation and fibrosis by intratracheal instillation of polyhexamethyleneguanidine phosphate
- Establishment of a mouse model for pulmonary inflammation and fibrosis by intratracheal instillation of polyhexamethyleneguanidine phosphate
- Lee, SJ[Lee, Sang Jin]; Park, JH[Park, Jong-Hwan]; Lee, JY[Lee, Jun-Young]; Jeong, YJ[Jeong, Yu-Jin]; Song, JA[Song, Jeong Ah]; Lee, K[Lee, Kyuhong]; Kim, DJ[Kim, Dong-Jae]
- DGIST Authors
- Kim, DJ[Kim, Dong-Jae]
- Issue Date
- Journal of Toxicologic Pathology, 29(2), 95-102
- Article Type
- Animal Experiment; Animal Model; Animal Tissue; Controlled Study; CXCL1 Chemokine; Cytokine Production; Disease Severity; Female; Histopathology; Interleukin-6; Lung Fibrosis; Lung Infiltrate; Lung Inflammation; Lung Parenchyma; Mice; Monocyte Chemotactic Protein 1; Mononuclear Cell; Mouse; Murine Model; Neutrophil; Non-Human; Phosphate; Pneumonia; Polyhexamethyleneguanidine Phosphate; Pulmonary Fibrosis; Transforming Growth Factor Beta; Tumor Necrosis Factor-Alpha; Unclassified Drug; Weight Change
- Although several animal models have been developed to study human pulmonary fibrosis, lack of a perfect model has raised the need for various animal models of pulmonary fibrosis. In this study, we evaluated the pulmonary effect of polyhexamethyleneguanidine phosphate instillation into the lungs of mice to determine the potential of these mice as a murine model of pulmonary fibrosis. Intratracheal instillation of polyhexamethyleneguanidine phosphate induced severe lung inflammation manifested by the infiltration of mononuclear cells and neutrophils and increased production of IL-6, TNF-α, CCL2 and CXCL1. The lung inflammation gradually increased until 28 days after polyhexamethyleneguanidine phosphate exposure, and increases of collagen deposition and TGF-β production, which are indicators of pulmonary fibrosis, were seen. Our study showed that intratracheal instillation of polyhexamethyleneguanidine phosphate induces pulmonary inflammation and fibrosis in mice. © 2016 The Japanese Society of Toxicologic Pathology.
- Japanese Society of Toxicologic Pathology
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- Laboratory Animal Resource Center1. Journal Articles
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