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Foundational dendritic processing that is independent of the cell type-specific structure in model primary neurons

Title
Foundational dendritic processing that is independent of the cell type-specific structure in model primary neurons
Authors
Kim, H[Kim, Hojeong]Heckman, CJ[Heckman, C. J.]
DGIST Authors
Kim, H[Kim, Hojeong]
Issue Date
2015-11-16
Citation
Neuroscience Letters, 609, 203-209
Type
Article
Article Type
Article
Keywords
Anatomic ModelAnimal CellCell StructureControlled StudyDendriteDendritic ExcitabilityDendritic StructureElectric PotentialModelNerve CellNerve Cell ExcitabilityNerve Cell Membrane PotentialNeuroanatomyNon-HumanPrimary NeuronsPriority JournalPyramidal Nerve CellRatReduced ModellingSignal PropagationSignal TransductionSpinal Cord MotoneuronSpinal Cord Nerve CellSynaptic Transmission
ISSN
0304-3940
Abstract
It has long been known that primary neurons in the brain and spinal cord exhibit very distinctive dendritic structures. However, it remains unclear whether dendritic processing for signal propagation and channel activation over dendrites is a function of the cell type-specific dendritic structure. By applying an extended analysis of signal attenuation for the physiological distributions of synaptic inputs and active channels on dendritic branches, we first demonstrate that regardless of their specific structure, all anatomically reconstructed models of primary neurons display a similar pattern of directional signal attenuation and locational channel activation over their dendrites. Then, using a novel modeling approach that allows direct comparison of the anatomically reconstructed primary neurons with their reduced models that exclusively retain anatomical dendritic signaling without being associated with structural specificity, we show that the reduced model can accurately predict dendritic excitability of the anatomical model in both passive and active mode. These results indicate that the directional signaling, locational excitability and their relationship are foundational features of dendritic processing that are independent of the cell type-specific structure across primary neurons. © 2015 Elsevier Ireland Ltd.
URI
http://hdl.handle.net/20.500.11750/2816
DOI
10.1016/j.neulet.2015.10.017
Publisher
Elsevier Ltd
Related Researcher
Files:
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Collection:
Companion Diagnostics and Medical Technology Research Group1. Journal Articles


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