Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hur, Wonhee | - |
dc.contributor.author | Lee, Joon Ho | - |
dc.contributor.author | Kim, Sung Woo | - |
dc.contributor.author | Kim, Jung-Hee | - |
dc.contributor.author | Bae, Si Hyun | - |
dc.contributor.author | Kim, Minhyung | - |
dc.contributor.author | Hwang, Daehee | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Park, Taesun | - |
dc.contributor.author | Um, Soo-Jong | - |
dc.contributor.author | Song, Byoung-Joon | - |
dc.contributor.author | Yoon, Seung Kew | - |
dc.date.available | 2017-07-11T05:57:06Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2015-07 | - |
dc.identifier.issn | 1357-2725 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2885 | - |
dc.description.abstract | Mechanisms associated with the progression of non-alcoholic fatty liver disease (NAFLD) remain unclear. We attempted to identify the pattern of altered gene expression at different time points in a high fat diet (HFD)-induced NAFLD mouse model. The early up-regulated genes are mainly involved in the innate immune responses, while the late up-regulated genes represent the inflammation processes. Although recent studies have shown that microRNAs play important roles in hepatic metabolic functions, the pivotal role of microRNAs in the progression of NAFLD is not fully understood. We investigated the functions of miR-451, which was identified as a target gene in the inflammatory process in NAFLD. miR-451 expression was significantly decreased in the palmitate (PA)-exposed HepG2 cells and in liver tissues of HFD-induced non-alcoholic steatohepatitis (NASH) mice. Its decreased expressions were also observed in liver specimens of NASH patients. In vitro analysis of the effect of miR-451 on proinflammatory cytokine provided evidence for negative regulation of PA-induced interleukin (IL)-8 and tumor necrosis factor-alpha (TNF-α) production. Furthermore, miR-451 over-expression inhibited translocation of the PA-induced NF-κB p65 subunit into the nucleus. Our result showed that Cab39 is a direct target of miRNA-451 in steatotic cells. Further study showed that AMPK activated through Cab39 inhibits NF-κB transactivation induced in steatotic HepG2 cells. miR-451 over-expression in steatotic cells significantly suppressed PA-induced inflammatory cytokine. These results provide new insights into the negative regulation of miR-451 in fatty acid-induced inflammation via the AMPK/AKT pathway and demonstrate potential therapeutic applications for miR-451 in preventing the progression from simple steatosis to severely advanced liver disease. © 2015 The Authors. Published by Elsevier Ltd. | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Downregulation of microRNA-451 in non-alcoholic steatohepatitis inhibits fatty acid-induced proinflammatory cytokine production through the AMPK/AKT pathway | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biocel.2015.04.016 | - |
dc.identifier.scopusid | 2-s2.0-84929308803 | - |
dc.identifier.bibliographicCitation | International Journal of Biochemistry and Cell Biology, v.64, pp.265 - 276 | - |
dc.subject.keywordAuthor | Non-alcoholic fatty liver | - |
dc.subject.keywordAuthor | Non-alcoholic steatohepatitis | - |
dc.subject.keywordAuthor | MicroRNAs | - |
dc.subject.keywordAuthor | MicroRNA-451 | - |
dc.subject.keywordAuthor | Cab39/MO25 | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordPlus | Adenylate Kinase | - |
dc.subject.keywordPlus | Adverse Effects | - |
dc.subject.keywordPlus | Angiogenesis | - |
dc.subject.keywordPlus | Animal | - |
dc.subject.keywordPlus | Animal Experiment | - |
dc.subject.keywordPlus | Animal Model | - |
dc.subject.keywordPlus | Animal Tissue | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | Base Sequence | - |
dc.subject.keywordPlus | Binding Site | - |
dc.subject.keywordPlus | Binding Sites | - |
dc.subject.keywordPlus | Biosynthesis | - |
dc.subject.keywordPlus | C57BL Mouse | - |
dc.subject.keywordPlus | Cab39/MO25 | - |
dc.subject.keywordPlus | Calcium-Binding Proteins | - |
dc.subject.keywordPlus | Calcium Binding Protein | - |
dc.subject.keywordPlus | Cell Fractionation | - |
dc.subject.keywordPlus | Controlled Study | - |
dc.subject.keywordPlus | Cytokine | - |
dc.subject.keywordPlus | Cytokine Production | - |
dc.subject.keywordPlus | Cytokines | - |
dc.subject.keywordPlus | Diet, High-Fat | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | Down Regulation | - |
dc.subject.keywordPlus | Enzyme Linked Immunosorbent Assay | - |
dc.subject.keywordPlus | Fatty ACID | - |
dc.subject.keywordPlus | Gene Expression | - |
dc.subject.keywordPlus | Genetics | - |
dc.subject.keywordPlus | Hep G2 Cells | - |
dc.subject.keywordPlus | Hepg2 Cell Line | - |
dc.subject.keywordPlus | Human | - |
dc.subject.keywordPlus | Human Cell | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Immunoglobulin Enhancer Binding Protein | - |
dc.subject.keywordPlus | Immunology | - |
dc.subject.keywordPlus | Inflammation | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | INTERLEUKIN-8 | - |
dc.subject.keywordPlus | Interleukin 8 | - |
dc.subject.keywordPlus | KINASE ACTIVATION | - |
dc.subject.keywordPlus | Lipid Diet | - |
dc.subject.keywordPlus | Liver | - |
dc.subject.keywordPlus | LIVER-DISEASE | - |
dc.subject.keywordPlus | LKB1-STRAD-MO25 COMPLEX | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Metabolism | - |
dc.subject.keywordPlus | Mice, Inbred C57BL | - |
dc.subject.keywordPlus | Microrna | - |
dc.subject.keywordPlus | Microrna-451 | - |
dc.subject.keywordPlus | Microrna 451 | - |
dc.subject.keywordPlus | Micrornas | - |
dc.subject.keywordPlus | MIR-451 | - |
dc.subject.keywordPlus | Mirn451 microRNA, Mouse | - |
dc.subject.keywordPlus | Mouse | - |
dc.subject.keywordPlus | Mus | - |
dc.subject.keywordPlus | Non-Alcoholic Fatty Liver | - |
dc.subject.keywordPlus | Non-Alcoholic Fatty Liver Disease | - |
dc.subject.keywordPlus | Non-Alcoholic Steatohepatitis | - |
dc.subject.keywordPlus | Nonalcoholic Fatty Liver | - |
dc.subject.keywordPlus | Nonhuman | - |
dc.subject.keywordPlus | Nucleotide Sequence | - |
dc.subject.keywordPlus | P38 MAPK | - |
dc.subject.keywordPlus | Palmitic ACID | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | Protein Kinase B | - |
dc.subject.keywordPlus | Proto-Oncogene Proteins C-AKT | - |
dc.subject.keywordPlus | Real Time Polymerase Chain Reaction | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | Reverse Transcription Polymerase Chain Reaction | - |
dc.subject.keywordPlus | Small Interfering Rna | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | Tumor Necrosis Factor Alpha | - |
dc.subject.keywordPlus | Unclassified Drug | - |
dc.subject.keywordPlus | Western Blotting | - |
dc.citation.endPage | 276 | - |
dc.citation.startPage | 265 | - |
dc.citation.title | International Journal of Biochemistry and Cell Biology | - |
dc.citation.volume | 64 | - |
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