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Pontin functions as an essential coactivator for Oct4-dependent lincRNA expression in mouse embryonic stem cells
- Pontin functions as an essential coactivator for Oct4-dependent lincRNA expression in mouse embryonic stem cells
- Boo, K[Boo, Kyungjin]; Bhin, J[Bhin, Jinhyuk]; Jeon, Y[Jeon, Yoon]; Kim, J[Kim, Joomyung]; Shin, HJR[Shin, Hi-Jai R.]; Park, JE[Park, Jong-Eun]; Kim, K[Kim, Kyeongkyu]; Kim, CR[Kim, Chang Rok]; Jang, H[Jang, Hyonchol]; Kim, IH[Kim, In-Hoo]; Kim, VN[Kim, V. Narry]; Hwang, D[Hwang, Daehee]; Lee, H[Lee, Ho]; Baek, SH[Baek, Sung Hee]
- DGIST Authors
- Hwang, D[Hwang, Daehee]
- Issue Date
- Nature Communications, 6
- Article Type
- The actions of transcription factors, chromatin modifiers and noncoding RNAs are crucial for the programming of cell states. Although the importance of various epigenetic machineries for controlling pluripotency of embryonic stem (ES) cells has been previously studied, how chromatin modifiers cooperate with specific transcription factors still remains largely elusive. Here, we find that Pontin chromatin remodelling factor plays an essential role as a coactivator for Oct4 for maintenance of pluripotency in mouse ES cells. Genome-wide analyses reveal that Pontin and Oct4 share a substantial set of target genes involved in ES cell maintenance. Intriguingly, we find that the Oct4-dependent coactivator function of Pontin extends to the transcription of large intergenic noncoding RNAs (lincRNAs) and in particular linc1253, a lineage programme repressing lincRNA, is a Pontin-dependent Oct4 target lincRNA. Together, our findings demonstrate that the Oct4-Pontin module plays critical roles in the regulation of genes involved in ES cell fate determination.
- Nature Publishing Group
- Related Researcher
Hwang, Dae Hee
Systems Biology and Medicine Lab
Multilayered spatiotemporal networks; Regulatory motifs or pathways; Metabolite-protein networks; Network stochasticity; Proteomics and informatics
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