Cited 2 time in webofscience Cited 5 time in scopus

Photothermal cancer therapy using graphitic carbon-coated magnetic particles prepared by one-pot synthesis

Title
Photothermal cancer therapy using graphitic carbon-coated magnetic particles prepared by one-pot synthesis
Authors
Lee, HJ[Lee, Hyo-Jeong]Sanetuntikul, J[Sanetuntikul, Jakkid]Choi, ES[Choi, Eun-Sook]Lee, BR[Lee, Bo Ram]Kim, JH[Kim, Jung-Hee]Kim, E[Kim, Eunjoo]Shanmugam, S[Shanmugam, Sangaraju]
DGIST Authors
Lee, HJ[Lee, Hyo-Jeong]; Sanetuntikul, J[Sanetuntikul, Jakkid]; Choi, ES[Choi, Eun-Sook]; Lee, BR[Lee, Bo Ram]; Kim, JH[Kim, Jung-Hee]; Kim, E[Kim, Eunjoo]Shanmugam, S[Shanmugam, Sangaraju]
Issue Date
2015
Citation
International Journal of Nanomedicine, 10, 271-282
Type
Article
Article Type
Article
Keywords
AbsorptionAdenocarcinomaAnimal ExperimentAnimal ModelBiocompatibilityCell DeathCell ViabilityChemical AnalyzerControlled StudyCytotoxicityFerromagnetic MaterialHumanHuman CellHydrodynamicsIron OxideMass SpectrometerMass SpectrometryMaterial CoatingMouseNear-Infrared SpectroscopyNon-HumanOne-Pot SynthesisOne Pot SynthesisParticle SizePhagocytosisPhotochemotherapyPhotothermal Cancer TherapyPhysical ChemistryRaman SpectrometryRaphitic Carbon-Encapsulated Magnetic NanoparticlesSpectrometerSurface PropertySynthesisThicknessTreatment ResponseTumor VolumeX Ray DiffractionZeta Potential
ISSN
1178-2013
Abstract
We describe here a simple synthetic strategy for the fabrication of carbon-coated Fe3O4 (Fe3O4@C) particles using a single-component precursor, iron (III) diethylenetriamine-pentaacetic acid complex. Physicochemical analyses revealed that the core of the synthesized particles consists of ferromagnetic Fe3O4 material ranging several hundred nanometers, embedded in nitrogen-doped graphitic carbon with a thickness of ~120 nm. Because of their photothermal activity (absorption of near-infrared [NIR] light), the Fe3O4@C particles have been investigated for photothermal therapeutic applications. An example of one such application would be the use of Fe3O4@C particles in human adenocarcinoma A549 cells by means of NIR-triggered cell death. In this system, the Fe3O4@C can rapidly generate heat, causing >98% cell death within 10 minutes under 808 nm NIR laser irradiation (2.3 W cm2). These Fe3O4@C particles provided a superior photothermal therapeutic effect by intratumoral delivery and NIR irradiation of tumor xenografts. These results demonstrate that one-pot synthesis of carbon-coated magnetic particles could provide promising materials for future clinical applications and encourage further investigation of this simple method. © 2015 Lee et al.
URI
http://hdl.handle.net/20.500.11750/2968
DOI
10.2147/IJN.S73128
Publisher
Dove Medical Press Ltd.
Related Researcher
Files:
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Collection:
Energy Science and EngineeringAdvanced Energy Materials Laboratory1. Journal Articles
Companion Diagnostics and Medical Technology Research Group1. Journal Articles


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