Cited 11 time in webofscience Cited 13 time in scopus

Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy

Title
Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy
Authors
Kim, HC[Kim, Hyun-Chul]Kim, E[Kim, Eunjoo]Jeong, SW[Jeong, Sang Won]Ha, TL[Ha, Tae-Lin]Park, SI[Park, Sang-Im]Lee, SG[Lee, Se Guen]Lee, SJ[Lee, Sung Jun]Lee, SW[Lee, Seung Woo]
DGIST Authors
Kim, HC[Kim, Hyun-Chul]Kim, E[Kim, Eunjoo]Jeong, SW[Jeong, Sang Won]; Ha, TL[Ha, Tae-Lin]; Park, SI[Park, Sang-Im]; Lee, SG[Lee, Se Guen]Lee, SJ[Lee, Sung Jun]
Issue Date
2015
Citation
Nanoscale, 7(39), 16470-16480
Type
Article
Article Type
Article
Keywords
AdenocarcinomaAlternating Magnetic FieldAnti-Cancer DrugCell Line, TumorChemistryChemotherapyDelayed-Action PreparationsDelayed Release FormulationDouble EffectsDoxorubicinDrug ProductsHumanHumansHyperthermia TherapyHyperthermia TreatmentsHyperthermia, InducedIron Oxide NanoparticleLung NeoplasmsMagnetic Nano-ParticlesMagnetismMetabolismMicelleMicellesNano-CarriersNanomagneticsNanoparticleNanoparticlesPathologyPharmacokineticsPharmacologyPolyethylene GlycolsPolymeric MicelleThermotherapyTumor Cell Line
ISSN
2040-3364
Abstract
Magnetic nanoparticle-conjugated polymeric micelles (MNP-PMs) consisting of poly(ethylene glycol)-poly(lactide) (PEG-PLA) and iron oxide nanoparticles were prepared and used as nanocarriers for combined hyperthermia and chemotherapy. Doxorubicin (DOX) was encapsulated in MNP-PMs, and an alternating magnetic field (AMF) resulted in an increase to temperature within a suitable range for inducing hyperthermia and a higher rate of drug release than observed without AMF. In vitro cytotoxicity and hyperthermia experiments were carried out using human lung adenocarcinoma A549 cells. When MNP-PMs encapsulated with an anticancer drug were used to treat A549 cells in combination with hyperthermia under AMF, 78% of the cells were killed by the double effects of heat and the drug, and the combination was more effective than either chemotherapy or hyperthermia treatment alone. Therefore, MNP-PMs encapsulated with an anticancer drug show potential for combined chemotherapy and hyperthermia. © The Royal Society of Chemistry.
URI
http://hdl.handle.net/20.500.11750/2977
DOI
10.1039/c5nr04130a
Publisher
Royal Society of Chemistry
Related Researcher
Files:
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Collection:
ETC1. Journal Articles
Companion Diagnostics and Medical Technology Research Group1. Journal Articles


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