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Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy
- Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy
- Kim, HC[Kim, Hyun-Chul]; Kim, E[Kim, Eunjoo]; Jeong, SW[Jeong, Sang Won]; Ha, TL[Ha, Tae-Lin]; Park, SI[Park, Sang-Im]; Lee, SG[Lee, Se Guen]; Lee, SJ[Lee, Sung Jun]; Lee, SW[Lee, Seung Woo]
- DGIST Authors
- Kim, HC[Kim, Hyun-Chul]; Kim, E[Kim, Eunjoo]; Jeong, SW[Jeong, Sang Won]; Ha, TL[Ha, Tae-Lin]; Park, SI[Park, Sang-Im]; Lee, SG[Lee, Se Guen]; Lee, SJ[Lee, Sung Jun]
- Issue Date
- Nanoscale, 7(39), 16470-16480
- Article Type
- Adenocarcinoma; Alternating Magnetic Field; Anti-Cancer Drug; Cell Line, Tumor; Chemistry; Chemotherapy; Delayed-Action Preparations; Delayed Release Formulation; Double Effects; Doxorubicin; Drug Products; Human; Humans; Hyperthermia Therapy; Hyperthermia Treatments; Hyperthermia, Induced; Iron Oxide Nanoparticle; Lung Neoplasms; Magnetic Nano-Particles; Magnetism; Metabolism; Micelle; Micelles; Nano-Carriers; Nanomagnetics; Nanoparticle; Nanoparticles; Pathology; Pharmacokinetics; Pharmacology; Polyethylene Glycols; Polymeric Micelle; Thermotherapy; Tumor Cell Line
- Magnetic nanoparticle-conjugated polymeric micelles (MNP-PMs) consisting of poly(ethylene glycol)-poly(lactide) (PEG-PLA) and iron oxide nanoparticles were prepared and used as nanocarriers for combined hyperthermia and chemotherapy. Doxorubicin (DOX) was encapsulated in MNP-PMs, and an alternating magnetic field (AMF) resulted in an increase to temperature within a suitable range for inducing hyperthermia and a higher rate of drug release than observed without AMF. In vitro cytotoxicity and hyperthermia experiments were carried out using human lung adenocarcinoma A549 cells. When MNP-PMs encapsulated with an anticancer drug were used to treat A549 cells in combination with hyperthermia under AMF, 78% of the cells were killed by the double effects of heat and the drug, and the combination was more effective than either chemotherapy or hyperthermia treatment alone. Therefore, MNP-PMs encapsulated with an anticancer drug show potential for combined chemotherapy and hyperthermia. © The Royal Society of Chemistry.
- Royal Society of Chemistry
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