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Modulation of Mitochondrial Function and Autophagy Mediates Carnosine Neuroprotection Against Ischemic Brain Damage

Title
Modulation of Mitochondrial Function and Autophagy Mediates Carnosine Neuroprotection Against Ischemic Brain Damage
Authors
Baek, SH[Baek, Seung-Hoon]Noh, AR[Noh, Ah Reum]Kim, KA[Kim, Kyeong-A.]Akram, M[Akram, Muhammad]Shin, YJ[Shin, Young-Jun]Kim, ES[Kim, Eun-Sun]Yu, SW[Yu, Seong Woon]Majid, A[Majid, Arshad]Bae, ON[Bae, Ok-Nam]
DGIST Authors
Yu, SW[Yu, Seong Woon]
Issue Date
2014-08
Citation
Stroke, 45(8), 2438-2443
Type
Article
Article Type
Article
Keywords
AnimalsAutophagyBrainBrain IschemiaCarnosineMaleMicrotubule-Associated ProteinsMitochondriaNeuronsNeuroprotective AgentsRatsRats, Sprague-DawleySignal TransductionStrokeTOR Serine-Threonine Kinases
ISSN
0039-2499
Abstract
BACKGROUND AND PURPOSE - : Despite the rapidly increasing global burden of ischemic stroke, no therapeutic options for neuroprotection against stroke currently exist. Recent studies have shown that autophagy plays a key role in ischemic neuronal death, and treatments that target autophagy may represent a novel strategy in neuroprotection. We investigated whether autophagy is regulated by carnosine, an endogenous pleiotropic dipeptide that has robust neuroprotective activity against ischemic brain damage. METHODS - : We examined the effect of carnosine on mitochondrial dysfunction and autophagic processes in rat focal ischemia and in neuronal cultures. RESULTS - : Autophagic pathways such as reduction of phosphorylated mammalian target of rapamycin (mTOR)/p70S6K and the conversion of microtubule-associated protein 1 light chain 3 (LC3)-I to LC3-II were enhanced in the ischemic brain. However, treatment with carnosine significantly attenuated autophagic signaling in the ischemic brain, with improvement of brain mitochondrial function and mitophagy signaling. The protective effect of carnosine against autophagy was also confirmed in primary cortical neurons. CONCLUSIONS - : Taken together, our data suggest that the neuroprotective effect of carnosine is at least partially mediated by mitochondrial protection and attenuation of deleterious autophagic processes. Our findings shed new light on the mechanistic pathways that this exciting neuroprotective agent influences. © 2014 American Heart Association, Inc.
URI
http://hdl.handle.net/20.500.11750/3063
DOI
10.1161/STROKEAHA.114.005183
Publisher
Lippincott Williams and Wilkins
Related Researcher
Files:
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Collection:
Brain and Cognitive SciencesETC1. Journal Articles


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