Cited 25 time in webofscience Cited 28 time in scopus

Magnetophoretic circuits for digital control of single particles and cells

Title
Magnetophoretic circuits for digital control of single particles and cells
Authors
Lim, B[Lim, Byeonghwa]Reddy, V[Reddy, Venu]Hu, X[Hu, XingHao]Kim, K[Kim, KunWoo]Jadhav, M[Jadhav, Mital]Abedini-Nassab, R[Abedini-Nassab, Roozbeh]Noh, YW[Noh, Young-Woock]Lim, YT[Lim, Yong Taik]Yellen, BB[Yellen, Benjamin B.]Kim, C[Kim, CheolGi]
DGIST Authors
Lim, B[Lim, Byeonghwa]; Reddy, V[Reddy, Venu]; Kim, C[Kim, CheolGi]
Issue Date
2014-05
Citation
Nature Communications, 5
Type
Article
Article Type
Article
Keywords
BiochemistryCell CommunicationColloidColloidsComputerComputersConductorDevicesElectric FieldGene SequenceHardwareHydrodynamicsIntegrated CircuitMagnetMagnetic FieldMagnetizationMagnetophoretic CircuitMagnetsNanoparticleNanoparticlesProceduresSemiconductorSingle-Cell AnalysisSynthesis
ISSN
2041-1723
Abstract
The ability to manipulate small fluid droplets, colloidal particles and single cells with the precision and parallelization of modern-day computer hardware has profound applications for biochemical detection, gene sequencing, chemical synthesis and highly parallel analysis of single cells. Drawing inspiration from general circuit theory and magnetic bubble technology, here we demonstrate a class of integrated circuits for executing sequential and parallel, timed operations on an ensemble of single particles and cells. The integrated circuits are constructed from lithographically defined, overlaid patterns of magnetic film and current lines. The magnetic patterns passively control particles similar to electrical conductors, diodes and capacitors. The current lines actively switch particles between different tracks similar to gated electrical transistors. When combined into arrays and driven by a rotating magnetic field clock, these integrated circuits have general multiplexing properties and enable the precise control of magnetizable objects. © 2014 Macmillan Publishers Limited.
URI
http://hdl.handle.net/20.500.11750/3093
DOI
10.1038/ncomms4846
Publisher
Nature Publishing Group
Files:
There are no files associated with this item.
Collection:
Emerging Materials ScienceETC1. Journal Articles


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