Cited 24 time in webofscience Cited 23 time in scopus

New Macrobicyclic Chelator for the Development of Ultrastable Cu-64-Radiolabeled Bioconjugate

Title
New Macrobicyclic Chelator for the Development of Ultrastable Cu-64-Radiolabeled Bioconjugate
Authors
Pandya, DN[Pandya, Darpan N.]Dale, AV[Dale, Ajit V.]Kim, JY[Kim, Jung Young]Lee, H[Lee, Hochun]Ha, YS[Ha, Yeong Su]An, GI[An, Gwang Il]Yoo, J[Yoo, Jeongsoo]
DGIST Authors
Lee, H[Lee, Hochun]
Issue Date
2012-03
Citation
Bioconjugate Chemistry, 23(3), 330-335
Type
Article
Article Type
Article
Keywords
Acetic AcidAnimalsBridged CompoundChelating AgentChelating AgentsChemical Reaction KineticsChromatography, High Pressure LiquidComplex FormationConjugateCopper 64Copper ComplexCopper RadioisotopesCyclam DerivativeEthyleneIsotope LabelingMacrocyclic CompoundMacrocyclic CompoundsMolecular StabilityPropyleneQuantitative AnalysisRatsRats, Sprague-DawleyReductionSpectrophotometry, UltravioletSynthesis
ISSN
1043-1802
Abstract
Ethylene cross-bridged cyclam with two acetate pendant arms, ECB-TE2A, is known to form the most kinetically stable 64Cu complexes. However, its usefulness as a bifunctional chelator is limited because of its harsh radiolabeling conditions. Herein, we report new cross-bridged cyclam chelator for the development of ultrastable 64Cu-radiolabeled bioconjugates. Propylene cross-bridged TE2A (PCB-TE2A) was successfully synthesized in an efficient way. The Cu(II) complex of PCB-TE2A exhibited much higher kinetic stability than ECB-TE2A in acid decomplexation studies, and also showed high resistance to reduction-mediated demetalation. Furthermore, the quantitative radiolabeling of PCB-TE2A with 64Cu was achieved under milder conditions compared to ECB-TE2A. Biodistribution studies strongly indicate that the 64Cu complexes of PCB-TE2A cleared out rapidly from the body with minimum decomplexation. © 2012 American Chemical Society.
URI
http://hdl.handle.net/20.500.11750/3385
DOI
10.1021/bc200539t
Publisher
American Chemical Society
Related Researcher
  • Author Lee, Ho Chun Electrochemistry Laboratory for Sustainable Energy(ELSE)
  • Research Interests Lithium-ion batteries; Novel Materials for rechargeable batteries; Novel energy conversion;storage systems; Electrochemistry; 리튬이차전지; 이차전지용 신규 전극 및 전해액; 신규 에너지변환 및 저장 시스템; 전기화학
Files:
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Collection:
Energy Science and EngineeringElectrochemistry Laboratory for Sustainable Energy(ELSE)1. Journal Articles


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