Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Jeon, Wonbae | - |
dc.date.available | 2017-07-11T07:04:53Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2011-01 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/3462 | - |
dc.description.abstract | A series of elastin-like proteins, SKGPG[V(VKG)3VKVPG]n-(ELP1-90)WP (n = 1, 2, 3, and 4), were biosynthesized based on the hydrophobic and lysine linkage domains of tropoelastin. The formation of self-assembled hydrophobic aggregates was monitored in order to determine the influence of cationic segments on phase transition properties as well as the sensitivity to changes in salt and pH. The thermal transition profiles of the proteins fused with only one or two cationic blocks (n = 1 or 2) were similar to that of the counterpart ELP1-90. In contrast, diblock proteins that contain 3 and 4 cationic blocks displayed a triphasic profile and no transition, respectively. Upon increasing the salt concentration and pH, a stimulus-induced phase transition from a soluble conformation to an insoluble aggregate was observed. The effects of cationic segments on the stimuli sensitivity of cationic bimodal ELPs were interpreted in terms of their structural and molecular characteristics. | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | Contribution of lysine-containing cationic domains to thermally-induced phase transition of elastin-like proteins and their sensitivity to different stimuli | - |
dc.type | Article | - |
dc.identifier.doi | 10.5483/BMBRep.2011.44.1.22 | - |
dc.identifier.wosid | 000286914200003 | - |
dc.identifier.scopusid | 2-s2.0-79751505034 | - |
dc.identifier.bibliographicCitation | BMB Reports, v.44, no.1, pp.22 - 27 | - |
dc.identifier.kciid | ART001521660 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordAuthor | Micellar assembly | - |
dc.subject.keywordAuthor | Cationic diblock biopolymers | - |
dc.subject.keywordAuthor | Elastin-like proteins | - |
dc.subject.keywordAuthor | Intelligent biomaterials | - |
dc.subject.keywordAuthor | Inverse phase transition | - |
dc.subject.keywordPlus | Extracellular Matrix Proteins | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | Hydrogen-Ion Concentration | - |
dc.subject.keywordPlus | Hydrophobic and Hydrophilic Interactions | - |
dc.subject.keywordPlus | Inorganic Salt | - |
dc.subject.keywordPlus | Intelligent Biomaterials | - |
dc.subject.keywordPlus | INTELLIGENT BIOSYNTHETIC NANOBIOMATERIALS | - |
dc.subject.keywordPlus | Inverse Phase Transition | - |
dc.subject.keywordPlus | Lysine | - |
dc.subject.keywordPlus | MEDICINE | - |
dc.subject.keywordPlus | Metabolism | - |
dc.subject.keywordPlus | Micellar Assembly | - |
dc.subject.keywordPlus | Molecular Genetics | - |
dc.subject.keywordPlus | Molecular Sequence Data | - |
dc.subject.keywordPlus | pH | - |
dc.subject.keywordPlus | Phase Transition | - |
dc.subject.keywordPlus | Polymers | - |
dc.subject.keywordPlus | Polypeptide | - |
dc.subject.keywordPlus | Protein Structure, Tertiary | - |
dc.subject.keywordPlus | Protein Tertiary Structure | - |
dc.subject.keywordPlus | Salts | - |
dc.subject.keywordPlus | Scleroprotein | - |
dc.subject.keywordPlus | TemPERATURE | - |
dc.subject.keywordPlus | Tropoelastin | - |
dc.subject.keywordPlus | Amino ACID Sequence | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | Biomaterials | - |
dc.subject.keywordPlus | Biopolymer | - |
dc.subject.keywordPlus | BIOPOLYMERS | - |
dc.subject.keywordPlus | Cationic Diblock Biopolymers | - |
dc.subject.keywordPlus | Chemical Phenomena | - |
dc.subject.keywordPlus | Chemistry | - |
dc.subject.keywordPlus | Elastin | - |
dc.subject.keywordPlus | Elastin-Like Proteins | - |
dc.citation.endPage | 27 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 22 | - |
dc.citation.title | BMB Reports | - |
dc.citation.volume | 44 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.type.docType | Article | - |
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