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Preparation of ketoprofen-loaded high-molecular weight poly(vinyl alcohol) gels
- Preparation of ketoprofen-loaded high-molecular weight poly(vinyl alcohol) gels
- Lim, HJ[Lim, Hyun Ju]; Lee, SJ[Lee, Sung Jun]; Choi, HG[Choi, Han Gon]; Kim, JA[Kim, Jung Ae]; Yong, CS[Yong, Chul Soon]; Han, SS[Han, Sung Soo]; Noh, SK[Noh, Seok Kyun]; Jang, J[Jang, Jinho]; Lyoo, WS[Lyoo, Won Seok]
- DGIST Authors
- Lee, SJ[Lee, Sung Jun]
- Issue Date
- Journal of Applied Polymer Science, 106(5), 3268-3272
- Article Type
- A-PVA Gel; Aging of Materials; Atactic Polymer; Gel; Gels; High-Molecular Weight; Ketoprofen; Molecular Weight; Morphology; Polymer Concentration; Polymerization; Polyvinyl Alcohol; Polyvinyl Alcohols; Swelling; Thermal Property; Water Mixture
- High-molecular-weight atactic poly(vinyl alcohol) (a-PVA) gels loaded with (R,S)-2-(3-benzoylphenyl)propionic acid (ketoprofen) were prepared from 5, 6, 7, and 8 g/dL solutions of a-PVA with a number-average degree of polymerization of 4000 in an ethylene glycol/ water mixture with an aging method to identify the effect of the initial polymer concentration on the swelling behavior, morphology, and thermal properties of a-PVA gels. Then, the release behavior of ketoprofen from a-PVA gels was investigated. As the polymer concentration decreased, the ability for network formation decreased, and the degree of swelling of the a-PVA gels increased. In addition, the enthalpy increased with an increase in the a-PVA concentration, but the melting temperatures of the gels prepared at different initial polymer concentrations were the same; this indicated that tighter gel networks would be formed by a higher polymer chain density. ©2007 Wiley Periodicals, Inc.
- John Wiley and Sons
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