Cited time in webofscience Cited time in scopus

Preparation of ketoprofen-loaded high-molecular weight poly(vinyl alcohol) gels

Title
Preparation of ketoprofen-loaded high-molecular weight poly(vinyl alcohol) gels
Author(s)
Lim, Hyun JuLee, Seong JunChoi, Han GonKim, Jung AeYong, Chul SoonHan, Sung SooNoh, Seok KyunJang, JinhoLyoo, Won Seok
Issued Date
2007-12
Citation
Journal of Applied Polymer Science, v.106, no.5, pp.3268 - 3272
Type
Article
Author Keywords
high-molecular weighta-PVA gelketoprofen
Keywords
Molecular WeightMorphologyPolymer ConcentrationPolymerizationPolyvinyl AlcoholPolyvinyl AlcoholsRELEASERICH PVA HYDROGELSSAPONIFICATIONSwellingThermal PropertyWATERWater MixtureA-Pva GelAging of MaterialsAtactic PolymerDIMETHYLSULFOXIDEDRUG-DELIVERY SystemGelGelsHigh-Molecular WeightKetoprofenMemBRANE
ISSN
0021-8995
Abstract
High-molecular-weight atactic poly(vinyl alcohol) (a-PVA) gels loaded with (R,S)-2-(3-benzoylphenyl)propionic acid (ketoprofen) were prepared from 5, 6, 7, and 8 g/dL solutions of a-PVA with a number-average degree of polymerization of 4000 in an ethylene glycol/ water mixture with an aging method to identify the effect of the initial polymer concentration on the swelling behavior, morphology, and thermal properties of a-PVA gels. Then, the release behavior of ketoprofen from a-PVA gels was investigated. As the polymer concentration decreased, the ability for network formation decreased, and the degree of swelling of the a-PVA gels increased. In addition, the enthalpy increased with an increase in the a-PVA concentration, but the melting temperatures of the gels prepared at different initial polymer concentrations were the same; this indicated that tighter gel networks would be formed by a higher polymer chain density. ©2007 Wiley Periodicals, Inc.
URI
http://hdl.handle.net/20.500.11750/3583
DOI
10.1002/app.25991
Publisher
John Wiley & Sons Inc.
Related Researcher
Files in This Item:

There are no files associated with this item.

Appears in Collections:
Division of Biomedical Technology 1. Journal Articles

qrcode

  • twitter
  • facebook
  • mendeley

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE