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Preparation of ketoprofen-loaded high-molecular weight poly(vinyl alcohol) gels

Title
Preparation of ketoprofen-loaded high-molecular weight poly(vinyl alcohol) gels
Authors
Lim, HJ[Lim, Hyun Ju]Lee, SJ[Lee, Sung Jun]Choi, HG[Choi, Han Gon]Kim, JA[Kim, Jung Ae]Yong, CS[Yong, Chul Soon]Han, SS[Han, Sung Soo]Noh, SK[Noh, Seok Kyun]Jang, J[Jang, Jinho]Lyoo, WS[Lyoo, Won Seok]
DGIST Authors
Lee, SJ[Lee, Sung Jun]
Issue Date
2007-12-05
Citation
Journal of Applied Polymer Science, 106(5), 3268-3272
Type
Article
Article Type
Article
Keywords
A-PVA GelAging of MaterialsAtactic PolymerGelGelsHigh-Molecular WeightKetoprofenMolecular WeightMorphologyPolymer ConcentrationPolymerizationPolyvinyl AlcoholPolyvinyl AlcoholsSwellingThermal PropertyWater Mixture
ISSN
0021-8995
Abstract
High-molecular-weight atactic poly(vinyl alcohol) (a-PVA) gels loaded with (R,S)-2-(3-benzoylphenyl)propionic acid (ketoprofen) were prepared from 5, 6, 7, and 8 g/dL solutions of a-PVA with a number-average degree of polymerization of 4000 in an ethylene glycol/ water mixture with an aging method to identify the effect of the initial polymer concentration on the swelling behavior, morphology, and thermal properties of a-PVA gels. Then, the release behavior of ketoprofen from a-PVA gels was investigated. As the polymer concentration decreased, the ability for network formation decreased, and the degree of swelling of the a-PVA gels increased. In addition, the enthalpy increased with an increase in the a-PVA concentration, but the melting temperatures of the gels prepared at different initial polymer concentrations were the same; this indicated that tighter gel networks would be formed by a higher polymer chain density. ©2007 Wiley Periodicals, Inc.
URI
http://hdl.handle.net/20.500.11750/3583
DOI
10.1002/app.25991
Publisher
John Wiley and Sons
Related Researcher
Files:
There are no files associated with this item.
Collection:
Magnetic-Controlled Materials Research Group1. Journal Articles


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