Cited 7 time in webofscience Cited 12 time in scopus

Detection of C-reactive protein using BioFET and extended gate

Title
Detection of C-reactive protein using BioFET and extended gate
Authors
Sohn, YS[Sohn, Young-Soo]Lee, SK[Lee, Sang-Kwon]Choi, SY[Choi, Sie-Young]
DGIST Authors
Sohn, YS[Sohn, Young-Soo]
Issue Date
2007-06
Citation
Sensor Letters, 5(2), 421-424
Type
Article
Article Type
Article
Keywords
Antigen-Antibody ReactionsBioassayBiochipsBioFETBiomarkersBiosensorsC-Reactive ProteinCmos Integrated CircuitsExtended-GateImmunoassayImmunosensorsMyocardial InfarctionPotentiometric SensorsProteins
ISSN
1546-198X
Abstract
A novel immunoassay based on a potentiometric measurement for C-reactive protein (CRP) has been developed using a BioFET and an extended gate. Both the BioFET and the extended gate were fabricated using CMOS process techniques. Id-Vd (drain voltage versus drain current) characteristics of the BioFET only and the BioFET with the extended gate were measured in PBS (phosphate buffered saline), after SAM (self-assembled monolayer) formation, after anti-CRP immobilization and after CRP antigen-antibody interaction. The relation between a current variation ratio and CRP concentration (3-10 μg/ml) was studied. Also, we observed the potential variation with increasing the area of the extended gate. The results show the feasibility of the BioFET and its integration with the extended gate for the detection of CRP In addition, it is expected that this sensing configuration could be used as a part of lab-on-a-chip for the detection of various other biomarkers. Copyright © 2007 American Scientific Publishers All rights reserved.
URI
http://hdl.handle.net/20.500.11750/3586
DOI
10.1166/sl.2007.216
Publisher
American Scientific Publishers
Files:
There are no files associated with this item.
Collection:
School of Undergraduate Studies1. Journal Articles


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