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dc.contributor.author Byun, Donghak -
dc.contributor.author Cho, Sung-Joon -
dc.contributor.author Lee, Byeong Han -
dc.contributor.author Min, Joongkee -
dc.contributor.author Lee, Jong-Hyun -
dc.contributor.author Kim, Sohee -
dc.date.available 2017-08-10T08:09:34Z -
dc.date.created 2017-08-09 -
dc.date.issued 2017-08 -
dc.identifier.issn 1741-2560 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/4124 -
dc.description.abstract Objective. Previously, we presented the fabrication and characterization of a flexible penetrating microelectrode array (FPMA) as a neural interface device. In the present study, we aim to prove the feasibility of the developed FPMA as a chronic intrafascicular recording tool for peripheral applications. Approach. For recording from the peripheral nerves of medium-sized animals, the FPMA was integrated with an interconnection cable and other parts that were designed to fit canine sciatic nerves. The uniformity of tip exposure and in vitro electrochemical properties of the electrodes were characterized. The capability of the device to acquire in vivo electrophysiological signals was evaluated by implanting the FPMA assembly in canine sciatic nerves acutely as well as chronically for 4 weeks. We also examined the histology of implanted tissues to evaluate the damage caused by the device. Main results. Throughout recording sessions, we observed successful multi-channel recordings (up to 73% of viable electrode channels) of evoked afferent and spontaneous nerve unit spikes with high signal quality (SNR > 4.9). Also, minor influences of the device implantation on the morphology of nerve tissues were found. Significance. The presented results demonstrate the viability of the developed FPMA device in the peripheral nerves of medium-sized animals, thereby bringing us a step closer to human applications. Furthermore, the obtained data provide a driving force toward a further study for device improvements to be used as a bidirectional neural interface in humans. © 2017 IOP Publishing Ltd. -
dc.language English -
dc.publisher Institute of Physics Publishing -
dc.title Recording nerve signals in canine sciatic nerves with a flexible penetrating microelectrode array -
dc.type Article -
dc.identifier.doi 10.1088/1741-2552/aa7493 -
dc.identifier.scopusid 2-s2.0-85031700203 -
dc.identifier.bibliographicCitation Journal of Neural Engineering, v.14, no.4, pp.1 - 14 -
dc.description.isOpenAccess FALSE -
dc.subject.keywordAuthor canine sciatic nerve -
dc.subject.keywordAuthor flexible penetrating microelectrode array (FPMA) -
dc.subject.keywordAuthor intrafascicular electrode -
dc.subject.keywordAuthor long-term implantation -
dc.subject.keywordAuthor nerve signal recording -
dc.subject.keywordAuthor neural electrode -
dc.subject.keywordAuthor neural interface -
dc.subject.keywordPlus Biocompatibility -
dc.subject.keywordPlus Canine Sciatic Nerve -
dc.subject.keywordPlus Cat -
dc.subject.keywordPlus Cuff Electrode -
dc.subject.keywordPlus Flexible Penetrating Microelectrode Array (FPMA) -
dc.subject.keywordPlus In Vivo -
dc.subject.keywordPlus Interface -
dc.subject.keywordPlus Intrafascicular Electrode -
dc.subject.keywordPlus Intrafascicular Electrodes -
dc.subject.keywordPlus Long Term Implantation -
dc.subject.keywordPlus Multichannel Electrode Time -
dc.subject.keywordPlus Nerve Signal Recording -
dc.subject.keywordPlus Neural Electrode -
dc.subject.keywordPlus Neural Interface -
dc.subject.keywordPlus Peripheral Nerve -
dc.subject.keywordPlus Pudendal Nerve -
dc.subject.keywordPlus Stimulation -
dc.citation.endPage 14 -
dc.citation.number 4 -
dc.citation.startPage 1 -
dc.citation.title Journal of Neural Engineering -
dc.citation.volume 14 -
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