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Comparison of desorption enhancement methods in the low temperature plasma ionization mass spectrometry for detecting fatty acids in Drosophila

Title
Comparison of desorption enhancement methods in the low temperature plasma ionization mass spectrometry for detecting fatty acids in Drosophila
Authors
Kim, Shin HyeJang, Hyun JunPark, Jeong HyangLee, Hyoung JunKim, JeongkwonYim, Yong-HyeonKim, Dan BeeYoon, Sohee
DGIST Authors
Park, Jeong Hyang
Issue Date
2017-08
Citation
Current Applied Physics, 17(8), 1120-1126
Type
Article
Article Type
Article
Keywords
Ambient ConditionsAmbient Mass SpectrometriesAmbient Mass SpectrometryChemical AnalysisChemical DetectionDamage DetectionDerivatizationDerivatizationsDesorptionEfficiencyElectrospray IonizationFatty AcidFatty AcidsHeating ConditionsHydrostatic PressureIonizationIonization EfficiencyLow Molecular WeightLow Temperature PlasmasMass SpectrometryMelanogasterMoleculesPlasmaPlasmasSelective AnalysisSpectrometryTarget MoleculeTemperatureVapor Pressure
ISSN
1567-1739
Abstract
Mass spectrometry (MS) with low temperature plasma (LTP) as an ionization source is one of the widely used ambient methods in analyzing various bio-chemical samples for their detection, identification, differentiation, etc. While the LTP-MS allows selective analysis of a sample with low-molecular weight without thermal damages, it has difficulties desorbing a target molecule from the sample surface with a low volatility. Hence, for the purpose of enhancing the desorption and ionization efficiencies of the LTP-MS when analyzing the fatty acids, two methods were compared: directly heating the sample surface and increasing the vapor pressure of the fatty acid itself by derivatization. In addition, the fatty acids in Drosophila were directly analyzed with the LTP-MS. As a result, it was found that the LTP-MS detection efficiency was enhanced with the derivatization as much as with the heating condition while there was little synergy in employing both of the heating and derivatization together. © 2017 Elsevier B.V.
URI
http://hdl.handle.net/20.500.11750/4127
DOI
10.1016/j.cap.2017.04.017
Publisher
Elsevier B.V.
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesSB LAB(Lab of Neurodegenerative diseases and Aging)1. Journal Articles


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