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Zebrafish as an animal model in epilepsy studies with multichannel EEG recordings

Title
Zebrafish as an animal model in epilepsy studies with multichannel EEG recordings
Authors
Cho, Sung-JoonByun, DonghakNam, Tai-SeungChoi, Seok-YongLee, Byung-GeunKim, Myeong-KyuKim, Sohee
DGIST Authors
Kim, Sohee
Issue Date
2017-06-08
Citation
Scientific Reports, 7
Type
Article
Article Type
Article
Keywords
ACIDAdult ZebrafishBiomarkerDiseaseDynamicsHigh Frequency OscillationsSeizuresSex DifferencesStatus EpilepticusStimulation
ISSN
2045-2322
Abstract
Despite recent interest in using zebrafish in human disease studies, sparked by their economics, fecundity, easy handling, and homologies to humans, the electrophysiological tools or methods for zebrafish are still inaccessible. Although zebrafish exhibit more significant larval-adult duality than any other animal, most electrophysiological studies using zebrafish are biased by using larvae these days. The results of larval studies not only differ from those conducted with adults but also are unable to delicately manage electroencephalographic montages due to their small size. Hence, we enabled noninvasive long-term multichannel electroencephalographic recording on adult zebrafish using customdesigned electrodes and perfusion system. First, we exploited demonstration of long-term recording on pentylenetetrazole-induced seizure models, and the results were quantified. Second, we studied skin- electrode impedance, which is crucial to the quality of signals. Then, seizure propagations and gender differences in adult zebrafish were exhibited for the first time. Our results provide a new pathway for future neuroscience research using zebrafish by overcoming the challenges for aquatic organisms such as precision, serviceability, and continuous water seepage. © The Author(s) 2017.
URI
http://hdl.handle.net/20.500.11750/4151
DOI
10.1038/s41598-017-03482-6
Publisher
Nature Publishing Group
Related Researcher
  • Author Kim, So Hee Neural Interfaces & MicroSystems Lab
  • Research Interests Neural interface; Neural stimulation; Bio MEMS; Stretchable electronics; Numerical simulation of implant-body interactions
Files:
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Collection:
Robotics EngineeringETC1. Journal Articles


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