Cited 3 time in webofscience Cited 4 time in scopus

Hierarchical gold nanostructures modified electrode for electrochemical detection of cancer antigen CA125

Title
Hierarchical gold nanostructures modified electrode for electrochemical detection of cancer antigen CA125
Authors
Torati, Sri RamuluKasturi, Krishna C. S. B.Lim, ByeonghwaKim, CheolGi
DGIST Authors
Torati, Sri Ramulu; Kasturi, Krishna C. S. B.; Lim, Byeonghwa; Kim, CheolGi
Issue Date
2017-05
Citation
Sensors and Actuators B-Chemical, 243, 64-71
Type
Article
Article Type
Article
Keywords
ArraysCA 125Carcinoembryonic AntigenDNA BiosensorElectrodepositionGlucoseGold NanostructuresHybridizationImmobilizationImmunosensorImpedimetric ImmunosensorMarkerNanoparticlesNonenzymatic DetectionOvarian Cancer
ISSN
0925-4005
Abstract
Gold nanostructures (GNs) modified electrode, which was fabricated by simple, cost-effective one-step electrochemical technique, was used for the development of an electrochemical immunosensor for the detection of CA125 antigen. The morphology of the GNs modified electrodes was easily controlled by changing the pH of the source gold electrolyte and the electrodeposition time. The GNs electrode has shown excellent electrochemical performance compared with flat bare Au electrode. Hence, the GNs electrode was used for the fabrication electrochemical immunosensor. The immobilization and sensing properties of the GNs modified bioelectrode is characterized by cyclic voltammetry, electrochemical impedance spectroscopy and differential pulse voltammetry with Fe(CN)(6)(3-/4-) as an electrochemical redox indicator. The developed GNs based electrochemical immunosensor offers good response for the detection of CM 25 antigen with a linear range (10-100 U mL(-1)), low detection limit (5.5 UmL(-1)). Thus, the fabricated immunosensor have potential applications as an enhance biosensing platform for biomolecules immobilization and detection. (C) 2016 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/4181
DOI
10.1016/j.snb.2016.11.127
Publisher
ELSEVIER SCIENCE SA
Files:
There are no files associated with this item.
Collection:
Emerging Materials ScienceLab for NanoBio-Materials & SpinTronics(nBEST)1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE