Cited 5 time in webofscience Cited 6 time in scopus

Protein-Induced Pluripotent Stem Cells Ameliorate and Reduce A beta Deposition of Alzheimer's Disease

Title
Protein-Induced Pluripotent Stem Cells Ameliorate and Reduce A beta Deposition of Alzheimer's Disease
Authors
Cha, Moon-YongKwon, Yoo-WookAhn, Hyo-SukJeong, HyobinLee, Yong YookMoon, MinhoBaik, Sung HoonKim, Dong KyuSong, HyundongYi, Eugene C.Hwang, DaeheeKim, Hyo-SooMook-Jung, Inhee
DGIST Authors
Hwang, Daehee
Issue Date
2017-01
Citation
Stem Cells Translational Medicine, 6(1), 293-305
Type
Article
Article Type
Article
Keywords
5XFAD miceActivationAlzheimer&aposs Disease (AD)Alzheimer&aposs Disease (AD)Amyloid Beta (A Beta)Central Nervous SystemGenerationIdentificationMechanismsMiceMouseOligodendrocyteOligodendrocyteProgenitor CellsProtein IpscProteomic Analysis
ISSN
2157-6564
Abstract
Transplantation of stem cells into the brain attenuates functional deficits in the central nervous system via cell replacement, the release of specific neurotransmitters, and the production of neurotrophic factors. To identify patient-specific and safe stem cells for treating Alzheimer’s disease (AD), we generated induced pluripotent stem cells (iPSCs) derived from mouse skin fibroblasts by treating protein extracts of embryonic stem cells. These reprogrammed cells were pluripotent but nontumorigenic. Here, we report that protein-iPSCs differentiated into glial cells and decreased plaque depositions in the 5XFAD transgenic AD mouse model. We also found that transplanted protein-iPSCs mitigated the cognitive dysfunction observed in these mice. Proteomic analysis revealed that oligodendrocyte-related genes were upregulated in brains injected with protein-iPSCs, providing new insights into the potential function of protein-iPSCs. Taken together, our data indicate that protein-iPSCs might be a promising therapeutic approach for AD. © 2016 The Authors.
URI
http://hdl.handle.net/20.500.11750/4249
DOI
10.5966/sctm.2016-0081
Publisher
AlphaMed Press
Related Researcher
  • Author Hwang, Dae Hee Systems Biology and Medicine Lab
  • Research Interests Multilayered spatiotemporal networks; Regulatory motifs or pathways; Metabolite-protein networks; Network stochasticity; Proteomics and informatics
Files:
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Collection:
New BiologyETC1. Journal Articles
ETC1. Journal Articles


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