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The cellular basis of dendrite pathology in neurodegenerative diseases

Title
The cellular basis of dendrite pathology in neurodegenerative diseases
Authors
Kweon, Jung HyunKim, SunhongLee, Sung Bae
DGIST Authors
Kweon, Jung Hyun; Lee, Sung Bae
Issue Date
2017
Citation
BMB Reports, 50(1), 5-11
Type
Article
Article Type
Article; Review
Keywords
Alzheimer&aposs Disease (AD)AnimalAnimalsAxonAxonsCognitive DeficitsCytoskeletonDegenerative DiseaseDendriteDendrite PathologyDendritesDopaminergic NeuronsGolgi OutpostsGolgi OutpostsHumanHumansIn VivoMicrotubule Stabilizing AgentMito ChondriaMitochondriaNerve CellNeurodegenerative DiseasesNeurodegenerative DiseasesNeuronsParkinson&aposs DiseasePathologySecretory PathwaySynaptic PlasticityTau Transgenic Mice
ISSN
1976-6696
Abstract
One of the characteristics of the neurons that distinguishesthem from other cells is their complex and polarized structureconsisting of dendrites, cell body, and axon. The complexityand diversity of dendrites are particularly well recognized, andaccumulating evidences suggest that the alterations in thedendrite structure are associated with many neurodegenerativediseases. Given the importance of the proper dendriticstructures for neuronal functions, the dendrite pathologyappears to have crucial contribution to the pathogenesis ofneurodegenerative diseases. Nonetheless, the cellular andmolecular basis of dendritic changes in the neurodegenerativediseases remains largely elusive. Previous studies in normalcondition have revealed that several cellular components,such as local cytoskeletal structures and organelles locatedlocally in dendrites, play crucial roles in dendrite growth. Byreviewing what has been unveiled to date regarding dendritegrowth in terms of these local cellular components, we aim toprovide an insight to categorize the potential cellular basis thatcan be applied to the dendrite pathology manifested in manyneurodegenerative diseases. © 2017 by the The Korean Society for Biochemistry and Molecular Biology.
URI
http://hdl.handle.net/20.500.11750/4250
DOI
10.5483/BMBRep.2017.50.1.131
Publisher
The Biochemical Society of the Republic of Korea
Related Researcher
  • Author Lee, Sung Bae SB LAB(Lab of Neurodegenerative diseases and Aging)
  • Research Interests Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
Files:
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Collection:
Brain and Cognitive SciencesETC1. Journal Articles


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