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Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice
- Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice
- Kim, Ok-Hee; Kim, Hyojung; Kang, Jinku; Yang, Dongki; Kang, Yu-Hoi; Lee, Dae Ho; Cheon, Gi Jeong; Park, Sang Chul; Oh, Byung-Chul
- DGIST Authors
- Park, Sang Chul
- Issue Date
- BMB Reports, 50(1), 43-48
- Article Type
- Activation; Aging; Aging; Animal; Animals; Anti Inflammatory Agents; Antigens, CD14; Anti Inflammatory Agent; Apoptosis; Apoptosis; Bone Marrow Cell; Bone Marrow Cells; C57Bl Mouse; CD14; CD14 Antigen; Cell Differentiation; Cell Differentiation; Clearance; Cytokine; Cytokines; Cytology; Disease; Expression; Homeostasis; Human; Humans; IL 10; Inflammation; Inflammation; Inflammation; Interleukin 10; Interleukin 10; Interleukin 10; Invariant Chain; Jurkat Cell Line; Jurkat Cells; Macrophage; Macrophages; Male; Male; Metabolism; Mice; Mice, Inbred C57BL; Mouse; Pathology; Phagocytosis; Phagocytosis; Physiology; Proliferation; Receptor
- Accumulation of tissue macrophages is a significant characteristic of disease-associated chronic inflammation, and facilitates the progression of disease pathology. However, the functional roles of these bone marrow-derived macrophages (BMDMs) in aging are unclear. Here, we identified agedependent macrophage accumulation in the bone marrow,showing that aging significantly increases the number of M1 macrophages and impairs polarization of BMDMs. We found that age-related dysregulation of BMDMs is associated with abnormal overexpression of the anti-inflammatory interleukin-10.BMDM dysregulation in aging impairs the expression levels of pro-inflammatory cytokines and genes involved in B-cell maturation and activation. Phagocytosis of apoptotic Jurkat cells by BMDMs was reduced because of low expression of phagocytic receptor CD14, indicating that increased apoptotic cells may result from defective phagocytosis of apoptotic cells in the BM of aged mice. Therefore, CD14 may represent a promising target for preventing BMDM dysregulation, and macrophage accumulation may provide diagnostic and therapeutic clues. © 2017 by the The Korean Society for Biochemistry and Molecular Biology.
- The Biochemical Society of the Republic of Korea
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