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Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice

Title
Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice
Authors
Kim, Ok-HeeKim, HyojungKang, JinkuYang, DongkiKang, Yu-HoiLee, Dae HoCheon, Gi JeongPark, Sang ChulOh, Byung-Chul
DGIST Authors
Park, Sang Chul
Issue Date
2017
Citation
BMB Reports, 50(1), 43-48
Type
Article
Article Type
Article
Keywords
ActivationAgingAgingAnimalAnimalsAnti Inflammatory AgentsAntigens, CD14Anti Inflammatory AgentApoptosisApoptosisBone Marrow CellBone Marrow CellsC57Bl MouseCD14CD14 AntigenCell DifferentiationCell DifferentiationClearanceCytokineCytokinesCytologyDiseaseExpressionHomeostasisHumanHumansIL 10InflammationInflammationInflammationInterleukin 10Interleukin 10Interleukin 10Invariant ChainJurkat Cell LineJurkat CellsMacrophageMacrophagesMaleMaleMetabolismMiceMice, Inbred C57BLMousePathologyPhagocytosisPhagocytosisPhysiologyProliferationReceptor
ISSN
1976-6696
Abstract
Accumulation of tissue macrophages is a significant characteristic of disease-associated chronic inflammation, and facilitates the progression of disease pathology. However, the functional roles of these bone marrow-derived macrophages (BMDMs) in aging are unclear. Here, we identified agedependent macrophage accumulation in the bone marrow,showing that aging significantly increases the number of M1 macrophages and impairs polarization of BMDMs. We found that age-related dysregulation of BMDMs is associated with abnormal overexpression of the anti-inflammatory interleukin-10.BMDM dysregulation in aging impairs the expression levels of pro-inflammatory cytokines and genes involved in B-cell maturation and activation. Phagocytosis of apoptotic Jurkat cells by BMDMs was reduced because of low expression of phagocytic receptor CD14, indicating that increased apoptotic cells may result from defective phagocytosis of apoptotic cells in the BM of aged mice. Therefore, CD14 may represent a promising target for preventing BMDM dysregulation, and macrophage accumulation may provide diagnostic and therapeutic clues. © 2017 by the The Korean Society for Biochemistry and Molecular Biology.
URI
http://hdl.handle.net/20.500.11750/4253
DOI
10.5483/BMBRep.2017.50.1.167
Publisher
The Biochemical Society of the Republic of Korea
Files:
There are no files associated with this item.
Collection:
New BiologyETC1. Journal Articles


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