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Histone lysine methylation and neurodevelopmental disorders

Title
Histone lysine methylation and neurodevelopmental disorders
Authors
Kim, Jeong-HoonLee, Jang HoLee, Im-SoonLee, Sung BaeCho, Kyoung Sang
DGIST Authors
Lee, Sung Bae
Issue Date
2017
Citation
International Journal of Molecular Sciences, 18(7)
Type
Article
Article Type
Review
Keywords
Beckwith Wiedemann SyndromeBMI1 ProteinEHMT1 GeneEmbryonic Ectoderm Development ProteinEmbryonic Stem CellEpigenetic ChangesEpigeneticsGene MutationH3K27 GeneH3K36 GeneH4K20 GeneHistone Lysine MethylationHistone Lysine MethylationHistone MethylationHumanKabuki Makeup SyndromeKMT2A GeneKMT2D GeneLysine DemethylaseLysine MethyltransferaseMental DeficiencyMental DiseaseMethylationMethylation RegulationMolecular DynamicsNervous System DevelopmentNeurodevelopmental DisorderNSD2 GeneNuclear FactorNuclear Factor I XPHF21A GenePHF8 GenePolycomb Repressive Complex 2Rap1 ProteinReviewSchizophreniaSetd1A GeneSodium Voltage Gated Channel Alpha Subunit 3Sotos SyndromeTranscription Factor EZH2Transcription Factor RUNX2Unclassified DrugV Set Domain Containing T Cell Activation Inhibitor 1Voltage Gated Sodium ChannelWhole Exome SequencingWolf Hirschhorn SyndromeX Linked Mental Retardation
ISSN
1661-6596
Abstract
Methylation of several lysine residues of histones is a crucial mechanism for relatively long-term regulation of genomic activity. Recent molecular biological studies have demonstrated that the function of histone methylation is more diverse and complex than previously thought. Moreover, studies using newly available genomics techniques, such as exome sequencing, have identified an increasing number of histone lysine methylation-related genes as intellectual disability-associated genes, which highlights the importance of accurate control of histone methylation during neurogenesis. However, given the functional diversity and complexity of histone methylation within the cell, the study of the molecular basis of histone methylation-related neurodevelopmental disorders is currently still in its infancy. Here, we review the latest studies that revealed the pathological implications of alterations in histone methylation status in the context of various neurodevelopmental disorders and propose possible therapeutic application of epigenetic compounds regulating histone methylation status for the treatment of these diseases. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/4273
DOI
10.3390/ijms18071404
Publisher
MDPI AG
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesSB LAB(Lab of Neurodegenerative diseases and Aging)1. Journal Articles


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