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Histone lysine methylation and neurodevelopmental disorders
- Histone lysine methylation and neurodevelopmental disorders
- Kim, Jeong-Hoon; Lee, Jang Ho; Lee, Im-Soon; Lee, Sung Bae; Cho, Kyoung Sang
- DGIST Authors
- Lee, Sung Bae
- Issue Date
- International Journal of Molecular Sciences, 18(7)
- Article Type
- Beckwith Wiedemann Syndrome; BMI1 Protein; EHMT1 Gene; Embryonic Ectoderm Development Protein; Embryonic Stem Cell; Epigenetic Changes; Epigenetics; Gene Mutation; H3K27 Gene; H3K36 Gene; H4K20 Gene; Histone Lysine Methylation; Histone Lysine Methylation; Histone Methylation; Human; Kabuki Makeup Syndrome; KMT2A Gene; KMT2D Gene; Lysine Demethylase; Lysine Methyltransferase; Mental Deficiency; Mental Disease; Methylation; Methylation Regulation; Molecular Dynamics; Nervous System Development; Neurodevelopmental Disorder; NSD2 Gene; Nuclear Factor; Nuclear Factor I X; PHF21A Gene; PHF8 Gene; Polycomb Repressive Complex 2; Rap1 Protein; Review; Schizophrenia; Setd1A Gene; Sodium Voltage Gated Channel Alpha Subunit 3; Sotos Syndrome; Transcription Factor EZH2; Transcription Factor RUNX2; Unclassified Drug; V Set Domain Containing T Cell Activation Inhibitor 1; Voltage Gated Sodium Channel; Whole Exome Sequencing; Wolf Hirschhorn Syndrome; X Linked Mental Retardation
- Methylation of several lysine residues of histones is a crucial mechanism for relatively long-term regulation of genomic activity. Recent molecular biological studies have demonstrated that the function of histone methylation is more diverse and complex than previously thought. Moreover, studies using newly available genomics techniques, such as exome sequencing, have identified an increasing number of histone lysine methylation-related genes as intellectual disability-associated genes, which highlights the importance of accurate control of histone methylation during neurogenesis. However, given the functional diversity and complexity of histone methylation within the cell, the study of the molecular basis of histone methylation-related neurodevelopmental disorders is currently still in its infancy. Here, we review the latest studies that revealed the pathological implications of alterations in histone methylation status in the context of various neurodevelopmental disorders and propose possible therapeutic application of epigenetic compounds regulating histone methylation status for the treatment of these diseases. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
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- Brain and Cognitive SciencesSB LAB(Lab of Neurodegenerative diseases and Aging)1. Journal Articles
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