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Nitrated proteome in human embryonic stem cells

Title
Nitrated proteome in human embryonic stem cells
Authors
Kang, Jeong WonHwang, DaeheeKim, Kwang Pyo
DGIST Authors
Hwang, Daehee
Issue Date
2016
Citation
Mass Spectrometry Letters, 7(4), 85-90
Type
Article
Article Type
Review
Keywords
Embryonic Stem CellsLC MS/MSNitrotyrosine EnrichmentProteomicsTyrosine Nitration
ISSN
2233-4203
Abstract
Post-translational modifications (PTMs) of proteins regulate self-renewal and differentiation in embryonic stem cells (ESCs). Nitration of tyrosine residues of proteins in ESCs modulates their downstream pathways, which can affect self-renewal and differentiation. However, protein tyrosine nitration (PTN) in ESCs has been rarely studied. We reviewed 23 nitrated sites in stem cell proteins. Functional enrichment analysis showed that these nitrated proteins are involved in signal transduction, cell adhesion and migration, and cell proliferation in ESCs. Comparison between the nitrated and known phosphorylated sites revealed that 7 nitrated sites had overlapping phosphorylated sites, indicating functional links of PTNs to their associated signaling pathways in ESCs. Therefore, nitrated proteome provides a basis for understanding potential roles of PTN in self-renewal and differentiation of ESCs. © 2016, Korean Society for Mass Spectrometry. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/4295
DOI
10.5478/MSL.2016.7.4.85
Publisher
Korean Society for Mass Spectrometry
Related Researcher
  • Author Hwang, Dae Hee Systems Biology and Medicine Lab
  • Research Interests Multilayered spatiotemporal networks; Regulatory motifs or pathways; Metabolite-protein networks; Network stochasticity; Proteomics and informatics
Files:
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Collection:
New BiologyETC1. Journal Articles
ETC1. Journal Articles


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