Cited 0 time in webofscience Cited 0 time in scopus

Neural Glycosylphosphatidylinositol-Anchored Proteins in Synaptic Specification

Title
Neural Glycosylphosphatidylinositol-Anchored Proteins in Synaptic Specification
Authors
Um, Ji WonKo, Jaewon
DGIST Authors
Um, Ji WonKo, Jaewon
Issue Date
2017-12
Citation
Trends in Cell Biology, 27(12), 931-945
Type
Article
Article Type
Review
Keywords
GPIAlzheimers-DiseaseAmyloid-BetaAutism Spectrum DisordersCaenorhabditis-ElegansCellular Prion ProteinGlutamate-Receptor 5Hippocampal NeurogenesisLipid RaftLipid RaftsMultiple-SclerosisNeural CircuitNeuronal Nogo-aSynapseSynaptic Adhesion
ISSN
0962-8924
Abstract
Glycosylphosphatidylinositol (GPI)-anchored proteins are a specialized class of lipid-associated neuronal membrane proteins that perform diverse functions in the dynamic control of axon guidance, synaptic adhesion, cytoskeletal remodeling, and localized signal transduction, particularly at lipid raft domains. Recent studies have demonstrated that a subset of GPI-anchored proteins act as critical regulators of synapse development by modulating specific synaptic adhesion pathways via direct interactions with key synapse-organizing proteins. Additional studies have revealed that alteration of these regulatory mechanisms may underlie various brain disorders. In this review, we highlight the emerging role of GPI-anchored proteins as key synapse organizers that aid in shaping the properties of various types of synapses and circuits in mammals. Neural GPI-anchored proteins have important roles in various aspects of central nervous system development, including axon guidance, synapse formation, transmission, and plasticity.These proteins are enriched at lipid rafts via heterogeneous mechanisms, acting to orchestrate the activation of various synaptic membrane proteins and intracellular signaling components.GPI-anchored proteins interact with various co-receptors that coordinate distinct extracellular and intracellular mechanisms associated with synaptic adhesion pathways.Neural GPI-anchored proteins and their co-receptors are implicated in various brain disorders, and elucidation of the precise molecular mechanisms underlying their involvement is crucial in advancing our understanding of synapse and neural circuit development, and in developing targeted therapies for various brain disorders. © 2017 Elsevier Ltd.
URI
http://hdl.handle.net/20.500.11750/4414
DOI
10.1016/j.tcb.2017.06.007
Publisher
Elsevier Ltd
Related Researcher
  • Author Ko, Jae Won Laboratory of Synapse Formation and Function
  • Research Interests Neuroendocine Regulation by Gut-Microbiota derived Small Chain fatty Acids (SCFA); Neural Immune Regulation by Medium/Small Chain Fatty Acids (MCFA); Odorant G-protein Coupled Receptors (GPCRs) Structure and Function; Ectopic Odorant GPCRs and Endocrine Diseases
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesUm Laboratory1. Journal Articles
Brain and Cognitive SciencesLaboratory of Synapse Formation and Function1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE