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Olfactory receptor 10J5 responding to Alpha-cedrene regulates hepatic steatosis via the cAMP-PKA pathway

Title
Olfactory receptor 10J5 responding to Alpha-cedrene regulates hepatic steatosis via the cAMP-PKA pathway
Authors
Tong, TaoRyu, Sang EunMin, YeojinDe March, Claire A.Bushdid, CarolineGolebiowski, JeromeMoon, CheilPark, Taesun
DGIST Authors
Moon, Cheil
Issue Date
2017
Citation
Scientific Reports, 7(1)
Type
Article
Article Type
Article
ISSN
2045-2322
Abstract
Ectopic expression and functions of odorant receptors (ORs) in the human body have aroused much interest in the past decade. Mouse olfactory receptor 23 (MOR23, olfr16) and its human orthologue, OR10J5, have been found to be functionally expressed in several non-olfactory systems. Here, using MOR23- and OR10J5-expressing Hana3A cells, we identified α-cedrene, a natural compound that protects against hepatic steatosis in mice fed the high-fat diet, as a novel agonist of these receptors. In human hepatocytes, an RNA interference-mediated knockdown of OR10J5 increased intracellular lipid accumulation, along with upregulation of lipogenic genes and downregulation of genes related to fatty acid oxidation. α-Cedrene stimulation resulted in a significant reduction in lipid contents of human hepatocytes and reprogramming of metabolic signatures, which are mediated by OR10J5, as demonstrated by receptor knockdown experiments using RNA interference. Taken together, our findings show a crucial role of OR10J5 in the regulation of lipid accumulation in human hepatocytes. © 2017 The Author(s).
URI
http://hdl.handle.net/20.500.11750/4431
DOI
10.1038/s41598-017-10379-x
Publisher
Nature Publishing Group
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesMoon Lab1. Journal Articles


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