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Beneficial effects of silibinin against kainic acidinduced neurotoxicity in the hippocampus in vivo
- Beneficial effects of silibinin against kainic acidinduced neurotoxicity in the hippocampus in vivo
- Kim, S.; Jung, U.J.; Oh, Yong Seok; Jeon, M.-T.; Kim, Hyung Jun; Shin, W.-H.; Hong, J.; Kim, S.
- DGIST Authors
- Oh, Yong Seok
- Issue Date
- Experimental Neurobiology, 26(5), 266-277
- Article Type
- Animal Cell; Animal Experiment; Animal Model; Animal Tissue; Antiinflammatory Activity; Apoptosis; Article; Autophagy; Caspase 3; Cell Death; Cell Structure; Controlled Study; Dentate Gyrus; Disease Predisposition; Dose Response; Drug Effect; Drug Potency; Epilepsy; Epileptic State; Frequency; Granule Cell; Granule Cell Dispersion; Hippocampus; Initiation Factor 4E Binding Protein 1; Interleukin 1Beta; Kainic Acid; Male; Mammalian Target Of Rapamycin Complex 1; Mouse; Nervous System Inflammation; Neuroprotection; Neurotoxicity; Nicotinamide Adenine Dinucleotide Adenosine Diphosphate; Ribosyltransferase 1; Nonhuman; P70 Ribosomal Protein S6 Kinase 1; Protein Expression; Protein Phosphorylation; Protein S6; Seizure; Silibinin; Spontaneous Recurrent Seizure; Temporal Lobe Epilepsy; Tumor Necrosis Factor; Unclassified Drug
- Silibinin, an active constituent of silymarin extracted from milk thistle, has been previously reported to confer protection to the adult brain against neurodegeneration. However, its effects against epileptic seizures have not been examined yet. In order to investigate the effects of silibinin against epileptic seizures, we used a relevant mouse model in which seizures are manifested as status epilepticus, induced by kainic acid (KA) treatment. Silibinin was injected intraperitoneally, starting 1 day before an intrahippocampal KA injection and continued daily until analysis of each experiment. Our results indicated that silibinin-treatment could reduce seizure susceptibility and frequency of spontaneous recurrent seizures (SRS) induced by KA administration, and attenuate granule cell dispersion (GCD), a morphological alteration characteristic of the dentate gyrus (DG) in temporal lobe epilepsy (TLE). Moreover, its treatment significantly reduced the aberrant levels of apoptotic, autophagic and pro-inflammatory molecules induced by KA administration, resulting in neuroprotection in the hippocampus. Thus, these results suggest that silibinin may be a beneficial natural compound for preventing epileptic events. © Experimental Neurobiology 2017.
- Korean Society for Neurodegenerative Disease
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- Brain and Cognitive SciencesLaboratory of Neural Signaling Networks1. Journal Articles
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