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Esr1+ cells in the ventromedial hypothalamus control female aggression
- Esr1+ cells in the ventromedial hypothalamus control female aggression
- Hashikawa, K.; Hashikawa, Y.; Tremblay, R.; Zhang, J.; Feng, J.E.; Sabol, A.; Piper, W.T.; Lee, Hyo Sang; Rudy, B.; Lin, D.
- DGIST Authors
- Lee, Hyo Sang
- Issue Date
- Nature Neuroscience, 20(11), 1580-1590
- Article Type
- Activity; Adult; Aggression; Animal; Animal Cell; Animal Experiment; Animal Tissue; Animals; Article; Biosynthesis; Brain Cell; Brain Function; C57Bl Mouse; Cell Activation; Controlled Study; Cytology; Electrical-Stimulation; Estrogen Receptor Alpha; Female; Fighting; Gene Expression; Hypothalamus Ventromedial Nucleus; Lordosis Reflex; Male; Male-Mice; Maternal Aggression; Mating; Medial Preoptic Area; Metabolism; Mice; Mice, Inbred C57Bl; Mice, Transgenic; Mouse; Nerve Cell; Neural; Neurons; Nonhuman; Nucleus; Physiology; Priority Journal; Progesterone Receptor; Psychology; Sexual Behavior; Sexual Behavior, Animal; Social Behavior; Transgenic Mouse; Ventromedial Hypothalamic Nucleus; Zona Incerta
- As an essential means of resolving conflicts, aggression is expressed by both sexes but often at a higher level in males than in females. Recent studies suggest that cells in the ventrolateral part of the ventromedial hypothalamus (VMHvl) that express estrogen receptor-α (Esr1) and progesterone receptor are essential for male but not female mouse aggression. In contrast, here we show that VMHvl Esr1+ cells are indispensable for female aggression. This population was active when females attacked naturally. Inactivation of these cells reduced female aggression whereas their activation elicited attack. Additionally, we found that female VMHvl contains two anatomically distinguishable subdivisions that showed differential gene expression, projection and activation patterns after mating and fighting. These results support an essential role of the VMHvl in both male and female aggression and reveal the existence of two previously unappreciated subdivisions in the female VMHvl that are involved in distinct social behaviors.
- Nature Publishing Group
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- Brain and Cognitive SciencesLaboratory of Affective Neuroscience1. Journal Articles
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