Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Park, Jiyoon | - |
dc.contributor.author | Chung, Chan | - |
dc.date.accessioned | 2024-01-30T11:10:12Z | - |
dc.date.available | 2024-01-30T11:10:12Z | - |
dc.date.created | 2023-12-22 | - |
dc.date.issued | 2023-04 | - |
dc.identifier.issn | 2288-2405 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/47709 | - |
dc.description.abstract | Diffuse midline glioma (DMG), hitherto known as diffuse intrinsic pontine glioma (DIPG), is a rare and aggressive form of brain cancer that primarily affects children. Although the exact cause of DMG/DIPG is not known, a large proportion of DMG/DIPG tumors harbor mutations in the gene encoding the histone H3 protein, specifically the H3K27M mutation. This mutation decreases the level of H3K27me3, a histone modification that plays a vital role in regulating gene expression through epigenetic regulation. The mutation also alters the function of polycomb repressive complex 2 (PRC2), thereby preventing the repression of genes associated with cancer development. The decrease in H3K27me3 caused by the histone H3 mutation is accompanied by an increase in the level of H3K27ac, a post-translational modification related to active transcription. Dysregulation of histone modification markedly affects gene expression, contributing to cancer development and progression by promoting uncontrolled cell proliferation, tumor growth, and metabolism. DMG/DIPG alters the metabolism of methionine and the tricarboxylic acid cycle, as well as glucose and glutamine uptake. The role of epigenetic and metabolic changes in the development of DMG/DIPG has been studied extensively, and understanding these changes is critical to developing therapies targeting these pathways. Studies are currently underway to identify new therapeutic targets for DMG/DIPG, which may lead to the development of effective treatments for this devastating disease. © 2023 The Korean Brain Tumor Society, The Korean Society for NeuroOncology, and The Korean Society for Pediatric Neuro-Oncology | - |
dc.language | English | - |
dc.publisher | 대한뇌종양학회 | - |
dc.title | Epigenetic and Metabolic Changes in Diffuse Intrinsic Pontine Glioma | - |
dc.type | Article | - |
dc.identifier.doi | 10.14791/btrt.2023.0011 | - |
dc.identifier.bibliographicCitation | Brain Tumor Research and Treatment, v.11, no.2, pp.86 - 93 | - |
dc.identifier.kciid | ART003024814 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordAuthor | Epigenomics | - |
dc.subject.keywordAuthor | Metabolomics | - |
dc.subject.keywordAuthor | Therapeutics | - |
dc.subject.keywordAuthor | Diffuse intrinsic pontine glioma | - |
dc.subject.keywordAuthor | Histone code | - |
dc.subject.keywordAuthor | Diffuse midline glioma. | - |
dc.citation.endPage | 93 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 86 | - |
dc.citation.title | Brain Tumor Research and Treatment | - |
dc.citation.volume | 11 | - |