Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Hojeong | ko |
dc.date.available | 2018-01-11T12:07:08Z | - |
dc.date.created | 2018-01-01 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.citation | Journal of Applied Physiology, v.123, no.5, pp.1166 - 1187 | - |
dc.identifier.issn | 8750-7587 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/4848 | - |
dc.description.abstract | The goal of this study is to investigate how the dendritic Ca-PIC location influences nonlinear input-output properties and depends on the type of motoneurons across the motoneuron pool. A model motoneuron pool consisting of 10 motoneurons was constructed using a recently developed two-compartment modeling approach that reflected key cell type-associated properties experimentally identified. The dendritic excitability and firing output depended systematically on both the PIC location and the motoneuron type. The PIC onset and offset in the current-voltage (I-V) relationship tended to occur at more hyperpolarized voltages as the path length to the PIC channels from the soma increased and as the cell type shifted from high- to lowthreshold motoneurons. At the same time, the firing acceleration and frequency hysteresis in the frequency-current (F-I) relationship became faster and larger, respectively. However, the PIC onset-offset hysteresis increased as the path length and the recruitment threshold increased. Furthermore, the gain of frequency-current function before full PIC activation was larger for PIC channels located over distal dendritic regions in low- compared with high-threshold motoneurons. When compared with previously published experimental observations, the modeling concurred when Ca-PIC channels were placed closer to the soma in high- than low-threshold motoneurons in the model motoneuron pool. All of these results suggest that the negative relationship of Ca-PIC location and cell recruitment threshold may underlie the systematic variation in I-V and F-I transformation across the motoneuron pool. NEW & NOTEWORTHY How does the dendritic location of calcium persistent inward current (Ca-PIC) influence dendritic excitability and firing behavior across the spinal motoneuron pool? This issue was investigated developing a model motoneuron pool that reflected key motoneuron type-specific properties experimentally identified. The simulation results point out the negative relationship between the distance of Ca-PIC source from the soma and cell recruitment threshold as a basis underlying the systematic variation in input-output properties of motoneurons over the motoneuron pool. © Copyright 2017 the American Physiological Society. | - |
dc.language | English | - |
dc.publisher | American Physiological Society | - |
dc.title | Impact of the localization of dendritic calcium persistent inward current on the input-output properties of spinal motoneuron pool: a computational study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1152/japplphysiol.00034.2017 | - |
dc.identifier.wosid | 000416597900018 | - |
dc.identifier.scopusid | 2-s2.0-85034026095 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.citationVolume | 123 | - |
dc.identifier.citationNumber | 5 | - |
dc.identifier.citationStartPage | 1166 | - |
dc.identifier.citationEndPage | 1187 | - |
dc.identifier.citationTitle | Journal of Applied Physiology | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | computational modeling | - |
dc.subject.keywordAuthor | dendritic calcium currents | - |
dc.subject.keywordAuthor | nonlinear firing behavior | - |
dc.subject.keywordAuthor | spinal motoneurons | - |
dc.subject.keywordAuthor | motoneuron pool | - |
dc.subject.keywordPlus | PLATEAU POTENTIALS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | SYSTEMATIC VARIATIONS | - |
dc.subject.keywordPlus | ELECTRICAL-PROPERTIES | - |
dc.subject.keywordPlus | HINDLIMB MOTONEURONS | - |
dc.subject.keywordPlus | INTRINSIC-PROPERTIES | - |
dc.subject.keywordPlus | LUMBAR MOTONEURONS | - |
dc.subject.keywordPlus | NEURON MODELS | - |
dc.subject.keywordPlus | CAT | - |
dc.subject.keywordPlus | BISTABILITY | - |
dc.contributor.affiliatedAuthor | Kim, Hojeong | - |
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