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Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis

Title
Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis
Authors
Bin, Bum-HoBhin, JinhyukTakaishi, MikiroToyoshima, Koh-eiKawamata, SaekoIto, KanaHara, TakafumiWatanabe, TakashiIrie, TarouTakagishi, TeruhisaLee, Su-HyonJung, Haeng-SunRho, SangchulSeo, JuyeonChoi, Dong-HwaHwang, Dae HeeKoseki, HaruhikoOhara, OsamuSano, ShigetoshiTsuji, TakashiMishima, KenjiFukada, Toshiyuki
DGIST Authors
Hwang, Dae Hee
Issue Date
2017-11
Citation
Proceedings of the National Academy of Sciences of the United States of America, 114(46), 12243-12248
Type
Article
Article Type
Article
Keywords
ACRODERMATITIS-ENTEROPATHICASTEM-CELLSGENE-EXPRESSIONHAIR FOLLICLEDNA-BINDINGRNA-SEQP63DIFFERENTIATIONSKINPROLIFERATION
ISSN
0027-8424
Abstract
Skin tissues, in particular the epidermis, are severely affected by zinc deficiency. However, the zinc-mediated mechanisms that maintain the cells that form the epidermis have not been established. Here, we report that the zinc transporter ZIP10 is highly expressed in the outer root sheath of hair follicles and plays critical roles in epidermal development. We found that ZIP10 marked epidermal progenitor cell subsets and that ablating Zip10 caused significant epidermal hypoplasia accompanied by down-regulation of the transactivation of p63, a master regulator of epidermal progenitor cell proliferation and differentiation. Both ZIP10 and p63 are significantly increased during epidermal development, in which ZIP10-mediated zinc influx promotes p63 transactivation. Collectively, these results indicate that ZIP10 plays important roles in epidermal development via, at least in part, the ZIP10–zinc–p63 signaling axis, thereby highlighting the physiological significance of zinc regulation in the maintenance of skin epidermis. © 2017, National Academy of Sciences. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/4854
DOI
10.1073/pnas.1710726114
Publisher
National Academy of Sciences
Files:
There are no files associated with this item.
Collection:
New BiologySystems Biology and Medicine Lab1. Journal Articles


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