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Proteomics in Rheumatoid Arthritis Research

Title
Proteomics in Rheumatoid Arthritis Research
Author(s)
Park, Yune-JungChung, Min KyungHwang, Dae HeeKim, Wan-Uk
Issued Date
2015-08
Citation
Immune Network, v.15, no.4, pp.177 - 185
Type
Article
Author Keywords
Rheumatoid arthritisProteomicsBiomarker
Keywords
FIBROBLAST-LIKE SYNOVIOCYTESBLOOD MONONUCLEAR-CELLSMASS-SPECTROMETRYCLASSIFICATION CRITERIADISEASE-ACTIVITYRHEUMATOLOGY/EUROPEAN LEAGUEPROTEIN EXPRESSIONAMERICAN-COLLEGERECOMMENDATIONSIDENTIFICATION
ISSN
1598-2629
Abstract
Although rheumatoid arthritis (RA) is the most common chronic inflammatory autoimmune disease, diagnosis of RA is currently based on clinical manifestations, and there is no simple, practical assessment tool in the clinical field to assess disease activity and severity. Recently, there has been increasing interest in the discovery of new diagnostic RA biomarkers that can assist in evaluating disease activity, severity, and treatment response. Proteomics, the largescale study of the proteome, has emerged as a powerful technique for protein identification and characterization.
For the past 10 years, proteomic techniques have been applied to different biological samples (synovial tissue/fluid, blood, and urine) from RA patients and experimental animal models. In this review, we summarize the current state of the application of proteomics in RA and its importance in identifying biomarkers and treatment targets.
URI
http://hdl.handle.net/20.500.11750/4903
DOI
10.4110/in.2015.15.4.177
Publisher
대한면역학회
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Department of New Biology Systems Biology and Medicine Lab 1. Journal Articles

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