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The neural connectivity of the inferior olivary nucleus in the human brain: A diffusion tensor tractography study
- The neural connectivity of the inferior olivary nucleus in the human brain: A diffusion tensor tractography study
- Jang, Sung Ho; Chang, Pyung-Hun; Kwon, Hyeok Gyu
- Issue Date
- Neuroscience Letters, 523(1), 67-70
- Article Type
- Adult; Capsula Interna; Cerebral Peduncle; Connectivity; Diffusion Tensor Imaging; Female; Functional Magnetic Resonance Imaging; Globus Pallidus; Human; Human Experiment; Humans; Inferior Olivary Nucleus; Inferior Olive; Male; Middle Aged; Motor Performance; Nerve Net; Neural Pathways; Neuroimaging; Normal Human; Nuclear Magnetic Resonance Scanner; Olivary Nucleus; Periaqueductal Gray Matter; Pons Angle; Posterior Parietal Cortex; Primary Motor Cortex; Primary Somatosensory Cortex; Priority Journal; Red Nucleus; Reproducibility of Results; Reticular Formation; Sensitivity and Specificity; Young Adult
- Objectives: Many animal studies have reported on the neural connectivity of the inferior olivary nucleus (ION). However, the neural connectivity of the ION has not been clearly elucidated in the human brain. In this study, the neural connectivity of the ION in the human brain was investigated by diffusion tensor imaging (DTI). Methods: Forty healthy subjects were recruited. DTIs were acquired using a sensitivity-encoding head coil at 1.5. T. Connectivity was defined as the incidence of connection between the ION and regions of interest (ROIs) in the brain. Results: In these subjects, the ION showed higher connectivity to the reticular formation (100%), the posterior limb of internal capsule (100%), the red nucleus (93.75%), the cerebral peduncle of midbrain (91.25%), the primary motor cortex (86.25%), the primary somatosensory cortex (85%), the periaqueductal gray mater (81.25%), the globus pallidus (81.25%), the anterior limb of internal capsule (62.5%), the pontine basis (62.5%), and the posterior parietal cortex (60%). Conclusions: The ION shows high connectivity with motor function-related areas, such as, the posterior limb of internal capsule, the red nucleus, the cerebral peduncle of midbrain, the primary motor cortex, and the pontine basis. These results indicate that the ION is closely related to motor function in the human brain. © 2012 Elsevier Ireland Ltd.
- Elsevier Ltd
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