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The neural connectivity of the inferior olivary nucleus in the human brain: A diffusion tensor tractography study

Title
The neural connectivity of the inferior olivary nucleus in the human brain: A diffusion tensor tractography study
Authors
Jang, Sung HoChang, Pyung-HunKwon, Hyeok Gyu
Issue Date
2012-08-08
Citation
Neuroscience Letters, 523(1), 67-70
Type
Article
Article Type
Article
Keywords
AdultCapsula InternaCerebral PeduncleConnectivityDiffusion Tensor ImagingFemaleFunctional Magnetic Resonance ImagingGlobus PallidusHumanHuman ExperimentHumansInferior Olivary NucleusInferior OliveMaleMiddle AgedMotor PerformanceNerve NetNeural PathwaysNeuroimagingNormal HumanNuclear Magnetic Resonance ScannerOlivary NucleusPeriaqueductal Gray MatterPons AnglePosterior Parietal CortexPrimary Motor CortexPrimary Somatosensory CortexPriority JournalRed NucleusReproducibility of ResultsReticular FormationSensitivity and SpecificityYoung Adult
ISSN
0304-3940
Abstract
Objectives: Many animal studies have reported on the neural connectivity of the inferior olivary nucleus (ION). However, the neural connectivity of the ION has not been clearly elucidated in the human brain. In this study, the neural connectivity of the ION in the human brain was investigated by diffusion tensor imaging (DTI). Methods: Forty healthy subjects were recruited. DTIs were acquired using a sensitivity-encoding head coil at 1.5. T. Connectivity was defined as the incidence of connection between the ION and regions of interest (ROIs) in the brain. Results: In these subjects, the ION showed higher connectivity to the reticular formation (100%), the posterior limb of internal capsule (100%), the red nucleus (93.75%), the cerebral peduncle of midbrain (91.25%), the primary motor cortex (86.25%), the primary somatosensory cortex (85%), the periaqueductal gray mater (81.25%), the globus pallidus (81.25%), the anterior limb of internal capsule (62.5%), the pontine basis (62.5%), and the posterior parietal cortex (60%). Conclusions: The ION shows high connectivity with motor function-related areas, such as, the posterior limb of internal capsule, the red nucleus, the cerebral peduncle of midbrain, the primary motor cortex, and the pontine basis. These results indicate that the ION is closely related to motor function in the human brain. © 2012 Elsevier Ireland Ltd.
URI
http://hdl.handle.net/20.500.11750/5352
DOI
10.1016/j.neulet.2012.06.043
Publisher
Elsevier Ltd
Files:
There are no files associated with this item.
Collection:
ETC1. Journal Articles


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