Cited 0 time in webofscience Cited 0 time in scopus

CoMIC, the hidden dynamics of mitochondrial inner compartments

Title
CoMIC, the hidden dynamics of mitochondrial inner compartments
Authors
Cho, Bong KiSun, Woong
Issue Date
2017-12
Citation
BMB Reports, 50(12), 597-598
Type
Article
Article Type
Article
Keywords
CalciumConstrictionDivisionDrp1Mitochondria
ISSN
1976-6696
Abstract
Mitochondria have evolutionarily, functionally and structurally distinct outer- (OMM) and inner-membranes (IMM). Thus, mitochondrial morphology is controlled by independent but coordinated activity of fission and fusion of the OMM and IMM. Constriction and division of the OMM are mediated by endocytosis-like machineries, which include dynamin-related protein 1 with additional cytosolic vesicle scissoring machineries such as actin filament and Dynamin 2. However, structural alteration of the IMM during mitochondrial division has been poorly understood. Recently, we found that the IMM and the inner compartments undergo transient and reversible constriction prior to the OMM division, which we termed CoMIC, Constriction of Mitochondrial Inner Compartment. In this short review, we further discuss the evolutionary perspective and the regulatory mechanism of CoMIC during mitochondrial division. © 2017 by the The Korean Society for Biochemistry and Molecular Biology.
URI
http://hdl.handle.net/20.500.11750/5611
DOI
10.5483/BMBRep.2017.50.12.154
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Files:
There are no files associated with this item.
Collection:
ETC1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE