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흰쥐 삼차신경감각핵에서 P2X3와 TRPV1의 공존에 관한 연구

Title
흰쥐 삼차신경감각핵에서 P2X3와 TRPV1의 공존에 관한 연구
Translated Title
Coexpression of P2X3 with TRPV1 in the Rat Trigeminal Sensory Nuclei
Authors
문용석김홍태배용철류창현조이슬박매자백상규문제일김윤숙
DGIST Authors
문제일
Issue Date
2008
Citation
한국현미경학회지, 38(3), 151-157
Type
Article
Keywords
P2X3TRPV1Trigeminal ganglionTrigeminal caudalisImmunofluorescence
ISSN
2287-5123
Abstract
Trigeminal primary afferents expressing P2X3 or transient receptor potential vanilloid 1 (TRPV1) are involved in the transmission of nociceptive information. In order to characterize P2X3- and TRPV1-immunopositive neurons in the trigeminal ganglion (TG) and trigeminal caudal nucleus (Vc), we performed immunofluorescence experiments using anti- P2X3 and anti-TRPV1 antisera and a morphometric analysis. 77.4% (1,401/1,801) of all the P2X3-postive neurons coexpressed TRPV1 and 51.9% (1,401/2,698) of all the TRPV1- immunopositive neurons also costained for P2X3 in the TG. Immunoreactivity for both P2X3 and TRPV1 were present in medium-sized neurons but not in small- and large-sized neurons. P2X3- and/or TRPV1-immunopositive fibers were observed in the primary afferents and their associated axons in the Vc. These fibers and terminals were distributed in the superficial lamina of Vc: P2X3-immunopositive fibers and terminals were distributed in the lamina I and II, expecially in the inner part of lamina II (lamina IIi), whereas TRPV1-immunopositive ones were densely detected in the lamina I and outer part of lamina II (lamina IIo). Immunopositive fibers and terminals for both P2X3 and TRPV1 were observed on the border between lamina IIi and IIo. These results suggest that terminals coexpressing P2X3 and TRPV1 are involved in specific roles in the transmission and processing of orofacial nociceptive information.
URI
http://hdl.handle.net/20.500.11750/5744
Publisher
한국현미경학회
Related Researcher
Files:
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Collection:
Brain and Cognitive SciencesMoon Lab1. Journal Articles


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