Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Sehwan | - |
dc.contributor.author | Moon, Gyeong Joon | - |
dc.contributor.author | Oh, Yong-Seok | - |
dc.contributor.author | Park, Jungha | - |
dc.contributor.author | Shin, Won-Ho | - |
dc.contributor.author | Jeong, Jae Yeong | - |
dc.contributor.author | Choi, Kwang Shik | - |
dc.contributor.author | Jin, Byung Kwan | - |
dc.contributor.author | Kholodilov, Nikolai | - |
dc.contributor.author | Burke, Robert E | - |
dc.contributor.author | Kim, Hyung-Jun | - |
dc.contributor.author | Ha, Chang Man | - |
dc.contributor.author | Lee, Seok-Geun | - |
dc.contributor.author | Kim, Sang Ryong | - |
dc.date.accessioned | 2018-04-29T06:39:20Z | - |
dc.date.available | 2018-04-29T06:39:20Z | - |
dc.date.created | 2018-03-29 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.citation | Experimental and Molecular Medicine, v.50, no.2, pp.e440 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/6219 | - |
dc.description.abstract | We recently reported that adeno-associated virus serotype 1 (AAV1) transduction of murine nigral dopaminergic (DA) neurons with constitutively active ras homolog enriched in brain with a mutation of serine to histidine at position 16 [Rheb(S16H)] induced the production of neurotrophic factors, resulting in neuroprotective effects on the nigrostriatal DA system in animal models of Parkinson's disease (PD). To further investigate whether AAV1-Rheb(S16H) transduction has neuroprotective potential against neurotoxic inflammation, which is known to be a potential event related to PD pathogenesis, we examined the effects of Rheb(S16H) expression in nigral DA neurons under a neurotoxic inflammatory environment induced by the endogenous microglial activator prothrombin kringle-2 (pKr-2). Our observations showed that Rheb(S16H) transduction played a role in the neuroprotection of the nigrostriatal DA system against pKr-2-induced neurotoxic inflammation, even though there were similar levels of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1 beta), in the AAV1-Rheb(S16H)-treated substantia nigra (SN) compared to the SN treated with pKr-2 alone; the neuroprotective effects may be mediated by the activation of neurotrophic signaling pathways following Rheb(S16H) transduction of nigral DA neurons. We conclude that AAV1-Rheb(S16H) transduction of neuronal populations to activate the production of neurotrophic factors and intracellular neurotrophic signaling pathways may offer promise for protecting adult neurons from extracellular neurotoxic inflammation. | - |
dc.language | English | - |
dc.publisher | NLM (Medline) | - |
dc.title | Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/emm.2017.261 | - |
dc.identifier.wosid | 000427487800001 | - |
dc.identifier.scopusid | 2-s2.0-85054726521 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Experimental and Molecular Medicine | - |
dc.identifier.kciid | ART002316195 | - |
dc.contributor.nonIdAuthor | Kim, Sehwan | - |
dc.contributor.nonIdAuthor | Moon, Gyeong Joon | - |
dc.contributor.nonIdAuthor | Park, Jungha | - |
dc.contributor.nonIdAuthor | Shin, Won-Ho | - |
dc.contributor.nonIdAuthor | Jeong, Jae Yeong | - |
dc.contributor.nonIdAuthor | Choi, Kwang Shik | - |
dc.contributor.nonIdAuthor | Jin, Byung Kwan | - |
dc.contributor.nonIdAuthor | Kholodilov, Nikolai | - |
dc.contributor.nonIdAuthor | Burke, Robert E | - |
dc.contributor.nonIdAuthor | Kim, Hyung-Jun | - |
dc.contributor.nonIdAuthor | Ha, Chang Man | - |
dc.contributor.nonIdAuthor | Lee, Seok-Geun | - |
dc.contributor.nonIdAuthor | Kim, Sang Ryong | - |
dc.identifier.citationVolume | 50 | - |
dc.identifier.citationNumber | 2 | - |
dc.identifier.citationStartPage | e440 | - |
dc.identifier.citationTitle | Experimental and Molecular Medicine | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE BRAIN | - |
dc.subject.keywordPlus | SUBSTANTIA-NIGRA | - |
dc.subject.keywordPlus | NEUROTROPHIC FACTOR | - |
dc.subject.keywordPlus | MICROGLIAL ACTIVATION | - |
dc.subject.keywordPlus | PROTHROMBIN KRINGLE-2 | - |
dc.subject.keywordPlus | BDNF | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | GDNF | - |
dc.subject.keywordPlus | NEURODEGENERATION | - |
dc.contributor.affiliatedAuthor | Kim, Sehwan | - |
dc.contributor.affiliatedAuthor | Moon, Gyeong Joon | - |
dc.contributor.affiliatedAuthor | Oh, Yong-Seok | - |
dc.contributor.affiliatedAuthor | Park, Jungha | - |
dc.contributor.affiliatedAuthor | Shin, Won-Ho | - |
dc.contributor.affiliatedAuthor | Jeong, Jae Yeong | - |
dc.contributor.affiliatedAuthor | Choi, Kwang Shik | - |
dc.contributor.affiliatedAuthor | Jin, Byung Kwan | - |
dc.contributor.affiliatedAuthor | Kholodilov, Nikolai | - |
dc.contributor.affiliatedAuthor | Burke, Robert E | - |
dc.contributor.affiliatedAuthor | Kim, Hyung-Jun | - |
dc.contributor.affiliatedAuthor | Ha, Chang Man | - |
dc.contributor.affiliatedAuthor | Lee, Seok-Geun | - |
dc.contributor.affiliatedAuthor | Kim, Sang Ryong | - |