Modulation mechanisms of voltage-gated calcium channels
- Title
- Modulation mechanisms of voltage-gated calcium channels
- Author(s)
- Park, Cheon Gyu ; Suh, Byung Chang
- Issued Date
- 2018-04
- Citation
- Current Opinion in Physiology, v.2, pp.77 - 83
- Type
- Article
- Keywords
- CA2+ CHANNEL ; BETA-2E SUBUNIT ; PROTEIN-KINASE ; SKELETAL-MUSCLE ; CA(V)1.2 ; PHOSPHORYLATION ; TRAFFICKING ; PIP2 ; PHOSPHOINOSITIDES ; ALPHA(2)DELTA
- ISSN
- 2468-8673
- Abstract
- Voltage-gated calcium (CaV) channels mediate diverse essential physiological functions through membrane depolarization-induced Ca2+ influx. Malfunction of CaV channels causes various pathophysiological disorders. A wide range of cellular signals, including phosphoinositides, auxiliary CaV β subunits, Ca2+/calmodulin, and phosphorylation, are crucial for finely controlling the activity of CaV channels. Various interacting proteins, such as 14-3-3 protein, densin, and stac3, are also important in regulating the surface expression of CaV channels. Here, this review provides recent advances in the regulatory mechanisms of CaV channel gating and trafficking. © 2018 Elsevier Ltd
- Publisher
- Elsevier Ltd
- Related Researcher
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Suh, Byung-Chang
- Research Interests Molecular mechanisms of epilepsy and sensory pain transmission; Signaling mechanism of ion channel regulation and membrane excitability; 분자전기생리; 간질 및 통증의 분자적 기전 연구
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- Appears in Collections:
- Department of Brain Sciences Laboratory of Brain Signal and Synapse Research 1. Journal Articles
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