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Simultaneous blood flow and blood oxygenation measurements using a combination of diffuse speckle contrast analysis and near-infrared spectroscopy

Title
Simultaneous blood flow and blood oxygenation measurements using a combination of diffuse speckle contrast analysis and near-infrared spectroscopy
Authors
Seong, M[Seong, Myeongsu]Phillips, Z[Phillips, Zephaniah]Mai, PM[Phuong Minh Mai]Yeo, C[Yeo, Chaebeom]Song, C[Song, Cheol]Lee, K[Lee, Kijoon]Kim, JG[Kim, Jae Gwan]
DGIST Authors
Yeo, C[Yeo, Chaebeom]; Song, C[Song, Cheol]; Lee, K[Lee, Kijoon]
Issue Date
2016-02
Citation
Journal of Biomedical Optics, 21(2)
Type
Article
Article Type
Article
Keywords
Blood FlowBlood OxygenationDiffuse OpticsDiffuse Speckle Contrast AnalysisHemodynamicsNear-Infrared Spectroscopy
ISSN
1083-3668
Abstract
A combined diffuse speckle contrast analysis (DSCA)-near-infrared spectroscopy (NIRS) system is proposed to simultaneously measure qualitative blood flow and blood oxygenation changes in human tissue. The system employs an optical switch to alternate two laser sources at two different wavelengths and a CCD camera to capture the speckle image. Therefore, an optical density can be measured from two wavelengths for NIRS measurements and a speckle contrast can be calculated for DSCA measurements. In order to validate the system, a flow phantom test and an arm occlusion protocol for arterial and venous occlusion were performed. Shorter exposure times (<1 ms) show a higher drop (between 50% and 66%) and recovery of 1/KS2 values after occlusion (approximately 150%), but longer exposure time (3 ms) shows more consistent hemodynamic changes. For four subjects, the 1/KS2 values dropped to an average of 82.1±4.0% during the occlusion period and the average recovery of 1/KS2 values after occlusion was 109.1±0.8%. There was also an approximately equivalent amplitude change in oxyhemoglobin (OHb) and deoxyhemoglobin (RHb) during arterial occlusion (max RHb=0.0085±0.0024 mM/DPF, min OHb=-0.0057±0.0044 mM/DPF). The sensitivity of the system makes it a suitable modality to observe qualitative hemodynamic trends during induced physiological changes. © 2016 Society of Photo-Optical Instrumentation Engineers (SPIE).
URI
http://hdl.handle.net/20.500.11750/2298
DOI
10.1117/1.JBO.21.2.027001
Publisher
SPIE
Related Researcher
Files:
There are no files associated with this item.
Collection:
Robotics EngineeringETC1. Journal Articles


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