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AMP-activated protein kinase: implications on ischemic diseases

Title
AMP-activated protein kinase: implications on ischemic diseases
Authors
Ahn, YJ[Ahn, Yong-Joo]Kim, H[Kim, Hwewon]Lim, H[Lim, Heejin]Lee, M[Lee, Max]Kang, Y[Kang, Yuhyun]Moon, S[Moon, SangJun]Kim, HS[Kim, Hyeon Soo]Kim, HH[Kim, Hyung-Hwan]
DGIST Authors
Lim, H[Lim, Heejin]; Moon, S[Moon, SangJun]
Issue Date
2012-09-30
Citation
BMB Reports, 45(9), 489-495
Type
Article
Article Type
Review
Keywords
AMP-Activated Protein KinasesAMPKCalcium-Calmodulin-Dependent Protein Kinase KinaseCalcium Calmodulin Dependent Protein Kinase KinaseCaMKK BetaChemistryEndothelial Nitric Oxide SynthaseEnzymologyGlucoseHumanHumansHydroxymethylglutaryl Coenzyme A Reductase KinaseIschemiaLKB1MetabolismMultienzyme ComplexMultienzyme ComplexesNitric Oxide Synthase Type IIIPathologyProtein-Serine-Threonine KinasesProtein Serine Threonine KinaseReviewSignal TransductionSTK11 Protein, Human
ISSN
1976-6696
Abstract
Ischemia is a blockage of blood supply due to an embolism or a hemorrhage in a blood vessel. When an organ cannot receive oxygenated blood and can therefore no longer replenish its blood supply dueto ischemia, stresses, such as the disruption of blood glucose homeostasis, hypoglycemia and hypoxia, activate the AMPK complex. LKB1 and CaMKKβ are essential activators of the AMPK signaling pathway. AMPK triggers proangiogenic effects through the eNOS protein in tissues with ischemic conditions, where cells are vulnerable to apoptosis, autophagy and necrosis. The AMPK complex acts to restore blood glucose levels and ATP levels back to homeostasis. This review will discuss AMPK, as well as its key activators (LKB1 and CaMKKβ), as a central energy regulator and evaluate the upstream and downstream regulating pathways of AMPK. We will also discuss how we can control this important enzyme in ischemic conditions to prevent harmful effects in patients with vascular damage. © 2012 by the The Korean Society for Biochemistry and Molecular Biology.
URI
http://hdl.handle.net/20.500.11750/2457
DOI
10.5483/BMBRep.2012.45.9.169
Publisher
Korean Society for Molecular and Cellular Biology
Files:
Collection:
Robotics EngineeringCybernetics Laboratory1. Journal Articles
Robotics EngineeringETC1. Journal Articles


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