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AMP-activated protein kinase: implications on ischemic diseases
- AMP-activated protein kinase: implications on ischemic diseases
- Ahn, YJ[Ahn, Yong-Joo]; Kim, H[Kim, Hwewon]; Lim, H[Lim, Heejin]; Lee, M[Lee, Max]; Kang, Y[Kang, Yuhyun]; Moon, S[Moon, SangJun]; Kim, HS[Kim, Hyeon Soo]; Kim, HH[Kim, Hyung-Hwan]
- DGIST Authors
- Lim, H[Lim, Heejin]; Moon, S[Moon, SangJun]
- Issue Date
- BMB Reports, 45(9), 489-495
- Article Type
- AMP-Activated Protein Kinases; AMPK; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Calcium Calmodulin Dependent Protein Kinase Kinase; CaMKK Beta; Chemistry; Endothelial Nitric Oxide Synthase; Enzymology; Glucose; Human; Humans; Hydroxymethylglutaryl Coenzyme A Reductase Kinase; Ischemia; LKB1; Metabolism; Multienzyme Complex; Multienzyme Complexes; Nitric Oxide Synthase Type III; Pathology; Protein-Serine-Threonine Kinases; Protein Serine Threonine Kinase; Review; Signal Transduction; STK11 Protein, Human
- Ischemia is a blockage of blood supply due to an embolism or a hemorrhage in a blood vessel. When an organ cannot receive oxygenated blood and can therefore no longer replenish its blood supply dueto ischemia, stresses, such as the disruption of blood glucose homeostasis, hypoglycemia and hypoxia, activate the AMPK complex. LKB1 and CaMKKβ are essential activators of the AMPK signaling pathway. AMPK triggers proangiogenic effects through the eNOS protein in tissues with ischemic conditions, where cells are vulnerable to apoptosis, autophagy and necrosis. The AMPK complex acts to restore blood glucose levels and ATP levels back to homeostasis. This review will discuss AMPK, as well as its key activators (LKB1 and CaMKKβ), as a central energy regulator and evaluate the upstream and downstream regulating pathways of AMPK. We will also discuss how we can control this important enzyme in ischemic conditions to prevent harmful effects in patients with vascular damage. © 2012 by the The Korean Society for Biochemistry and Molecular Biology.
- Korean Society for Molecular and Cellular Biology
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