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Neuroprotective Effects of an Erythropoietin-Derived Peptide in PC12 Cells under Oxidative Stress

Title
Neuroprotective Effects of an Erythropoietin-Derived Peptide in PC12 Cells under Oxidative Stress
Authors
Yoo, SJ[Yoo, Seung-Jun]Cho, B[Cho, Bongki]Moon, C[Moon, Chanil]Yu, SW[Yu, Seong-Woon]Moon, C[Moon, Cheil]
DGIST Authors
Yoo, SJ[Yoo, Seung-Jun]; Cho, B[Cho, Bongki]; Yu, SW[Yu, Seong-Woon]Moon, C[Moon, Cheil]
Issue Date
2016
Citation
CNS and Neurological Disorders: Drug Targets, 15(8), 927-934
Type
Article
Article Type
Article
Keywords
ErythropoietinErythropoietin ReceptorNeuronal DeathPeptideProliferationReactive Oxygen Species (ROS)
ISSN
1871-5273
Abstract
Erythropoietin (EPO) has been shown to be a key cytokine in the production of erythrocytes from erythroblasts. Recently, attempts have been made to adopt EPO as a drug target for neuroprotection in selected neurological pathologies. In the current study, a novel EPO-derived peptide which mimics the weak binding site of EPO to its receptor (MK-X) was generated. Experimental results demonstrated that MK-X was able to ameliorate neuronal death due to reactive oxygen species and conditions of oxidative stress similar to EPO. In addition, MK-X induced long-lasting Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) and Akt activation. Furthermore, treatment with inhibitors of ERK1/2 and Akt abolished the neuroprotective effect of MK-X. Unlike EPO, however, MK-X did not induce cellular proliferation. Collectively, the results of the current study suggested that MK-X may be useful as a novel neuroprotective reagent. © 2016 Bentham Science Publishers.
URI
http://hdl.handle.net/20.500.11750/2768
DOI
10.2174/1871527315666160813223329
Publisher
Bentham Science Publisher
Related Researcher
Files:
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Collection:
Brain and Cognitive SciencesLaboratory of Neuronal Cell Death1. Journal Articles


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