Cited 4 time in
Cited 4 time in
Non-contact acoustic radiation force impulse microscopy via photoacoustic detection for probing breast cancer cell mechanics
- Non-contact acoustic radiation force impulse microscopy via photoacoustic detection for probing breast cancer cell mechanics
- Hwang, JY[Hwang, Jae Youn]; Kang, BJ[Kang, Bong Jin]; Lee, C[Lee, Changyang]; Kim, HH[Kim, Hyung Ham]; Park, J[Park, Jinhyoung]; Zhou, QF[Zhou, Qifa]; Shung, KK[Shung, K. Kirk]
- DGIST Authors
- Hwang, JY[Hwang, Jae Youn]
- Issue Date
- Biomedical Optics Express, 6(1), 11-22
- Article Type
- (170.0180) Microscopy; (170.5120) Photoacoustic Imaging; (170.7170) Ultrasound; Acoustic Emissions; Acoustic Radiation Force; Acoustic Radiation Force Impulse; Acoustic Radiation Force Impulse Imaging; Acoustic Radiators; Acoustic Wave Propagation; Acoustic Wave Transmission; Acoustic Waves; Article; Breast Cancer; Breast Cancer Cells; Cancer Cell; Carbon Nanotube; Cell Mechanics; Cell Membrane; Cell Membranes; Cells; Cytology; Diseases; Elasticity; Human; Human Cell; Imaging Phantom; Lithium Niobate Ultrasound Transducer; Mechanics; Membrane Displacement; Non-Contact Methods; Photo-Acoustic Detection; Photo-Acoustic Effect; Photo-Acoustic Imaging; Photo-Acoustic Microscopy; Photo-Acoustics; Radiotherapy; Signal Detection; Single-Cell Analysis; Single-Walled Carbon Nanotubes (SWCN); Ultrasonic Applications; Ultrasonic Transducers; Ultrasound Transducer; Ultrasound Transducers; Yarn; Young Modulus
- We demonstrate a novel non-contact method: acoustic radiation force impulse microscopy via photoacoustic detection (PA-ARFI), capable of probing cell mechanics. A 30 MHz lithium niobate ultrasound transducer is utilized for both detection of phatoacoustic signals and generation of acoustic radiation force. To track cell membrane displacements by acoustic radiation force, functionalized single-walled carbon nanotubes are attached to cell membrane. Using the developed microscopy evaluated with agar phantoms, the mechanics of highly- and weakly-metastatic breast cancer cells are quantified. These results clearly show that the PA-ARFI microscopy may serve as a novel tool to probe mechanics of single breast cancer cells. © 2014 Optical Society of America.
- OSA - The Optical Society
- Related Researcher
Hwang, Jae Youn
MBIS(Multimodal Biomedical Imaging and System) Laboratory
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