Cited 4 time in webofscience Cited 4 time in scopus

Non-contact acoustic radiation force impulse microscopy via photoacoustic detection for probing breast cancer cell mechanics

Title
Non-contact acoustic radiation force impulse microscopy via photoacoustic detection for probing breast cancer cell mechanics
Authors
Hwang, JY[Hwang, Jae Youn]Kang, BJ[Kang, Bong Jin]Lee, C[Lee, Changyang]Kim, HH[Kim, Hyung Ham]Park, J[Park, Jinhyoung]Zhou, QF[Zhou, Qifa]Shung, KK[Shung, K. Kirk]
DGIST Authors
Hwang, JY[Hwang, Jae Youn]
Issue Date
2015-01-01
Citation
Biomedical Optics Express, 6(1), 11-22
Type
Article
Article Type
Article
Keywords
(170.0180) Microscopy(170.5120) Photoacoustic Imaging(170.7170) UltrasoundAcoustic EmissionsAcoustic Radiation ForceAcoustic Radiation Force ImpulseAcoustic Radiation Force Impulse ImagingAcoustic RadiatorsAcoustic Wave PropagationAcoustic Wave TransmissionAcoustic WavesArticleBreast CancerBreast Cancer CellsCancer CellCarbon NanotubeCell MechanicsCell MembraneCell MembranesCellsCytologyDiseasesElasticityHumanHuman CellImaging PhantomLithium Niobate Ultrasound TransducerMechanicsMembrane DisplacementNon-Contact MethodsPhoto-Acoustic DetectionPhoto-Acoustic EffectPhoto-Acoustic ImagingPhoto-Acoustic MicroscopyPhoto-AcousticsRadiotherapySignal DetectionSingle-Cell AnalysisSingle-Walled Carbon Nanotubes (SWCN)Ultrasonic ApplicationsUltrasonic TransducersUltrasound TransducerUltrasound TransducersYarnYoung Modulus
ISSN
2156-7085
Abstract
We demonstrate a novel non-contact method: acoustic radiation force impulse microscopy via photoacoustic detection (PA-ARFI), capable of probing cell mechanics. A 30 MHz lithium niobate ultrasound transducer is utilized for both detection of phatoacoustic signals and generation of acoustic radiation force. To track cell membrane displacements by acoustic radiation force, functionalized single-walled carbon nanotubes are attached to cell membrane. Using the developed microscopy evaluated with agar phantoms, the mechanics of highly- and weakly-metastatic breast cancer cells are quantified. These results clearly show that the PA-ARFI microscopy may serve as a novel tool to probe mechanics of single breast cancer cells. © 2014 Optical Society of America.
URI
http://hdl.handle.net/20.500.11750/2944
DOI
10.1364/BOE.6.000011
Publisher
OSA - The Optical Society
Related Researcher
  • Author Hwang, Jae Youn MBIS(Multimodal Biomedical Imaging and System) Laboratory
  • Research Interests
Files:
There are no files associated with this item.
Collection:
Information and Communication EngineeringETC1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE