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Current status of PET-imaging probes of beta-amyloid plaques

Title
Current status of PET-imaging probes of beta-amyloid plaques
Authors
Koo, J[Koo, JaeHyung]Byun, Y[Byun, Youngjoo]
DGIST Authors
Koo, J[Koo, JaeHyung]
Issue Date
2013-10
Citation
Archives of Pharmacal Research, 36(10), 1178-1184
Type
Article
Article Type
Review
Keywords
Alzheimer&aposs Disease (AD)AmnesiaAmyloid PlaqueAmyloid PlaquesAniline CompoundsAzd 4694Bay 1008472BenzeneBinding AffinityCarbon 11DementiaEarly DiagnosisEthylene GlycolsFlorbetapir F 18Fluorine 18Flutemetamol F 18Food and Drug AdministrationHigh Throughput ScreeningHistopathologyHumanHumansHydroxyl GroupMacrogolMetabolic RateNon-HumanPet-ImagingPiperazine DerivativePlaque, AmyloidPositron-Emission TomographyPositron-Emission Tomography (PET)PyridinePyridinylbenzoxazole DerivativeRadiopharmaceutical AgentReviewScintiscanningSensitivity and SpecificityStilbeneStilbene DerivativeStructure Activity RelationUnclassified Drug
ISSN
0253-6269
Abstract
Alzheimer's disease (AD) is the most common form of dementia and is characterized by progressive cognitive decline and memory loss. One of pathological hallmarks of AD is the accumulation and deposition of β-amyloid (Aβ) plaques which is a potential target for the early diagnosis of AD. Positron emission tomography (PET), a sensitive radionuclide imaging technique, has provided opportunities to detect Aβ plaques of AD. PET-imaging probes of Aβ plaques have been extensively developed during the last decade. [18F]Florbetapir, the 18F-labeled PET-imaging probe of Aβ plaques, was recently approved by US Food and Drug Administration. A number of follow-on PET-imaging probes are currently being developed in academia and pharmaceutical companies. This article will discuss the recent development of PET-imaging probes from [11C]PIB to [ 18F]Florbetapir, which are in clinic trials, and several follow-on probes in preclinical stage. © 2013 The Pharmaceutical Society of Korea.
URI
http://hdl.handle.net/20.500.11750/3201
DOI
10.1007/s12272-013-0193-4
Publisher
Pharmaceutical Society of Korea
Related Researcher
  • Author Koo, Jae Hyung The Koo Lab - ChemoReception Laboratory(CRLab)
  • Research Interests
Files:
There are no files associated with this item.
Collection:
New BiologyETC1. Journal Articles


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