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Current status of PET-imaging probes of beta-amyloid plaques
- Current status of PET-imaging probes of beta-amyloid plaques
- Koo, J[Koo, JaeHyung]; Byun, Y[Byun, Youngjoo]
- DGIST Authors
- Koo, J[Koo, JaeHyung]
- Issue Date
- Archives of Pharmacal Research, 36(10), 1178-1184
- Article Type
- Alzheimer' s Disease (AD); Amnesia; Amyloid Plaque; Amyloid Plaques; Aniline Compounds; Azd 4694; Bay 1008472; Benzene; Binding Affinity; Carbon 11; Dementia; Early Diagnosis; Ethylene Glycols; Florbetapir F 18; Fluorine 18; Flutemetamol F 18; Food and Drug Administration; High Throughput Screening; Histopathology; Human; Humans; Hydroxyl Group; Macrogol; Metabolic Rate; Non-Human; Pet-Imaging; Piperazine Derivative; Plaque, Amyloid; Positron-Emission Tomography; Positron-Emission Tomography (PET); Pyridine; Pyridinylbenzoxazole Derivative; Radiopharmaceutical Agent; Review; Scintiscanning; Sensitivity and Specificity; Stilbene; Stilbene Derivative; Structure Activity Relation; Unclassified Drug
- Alzheimer's disease (AD) is the most common form of dementia and is characterized by progressive cognitive decline and memory loss. One of pathological hallmarks of AD is the accumulation and deposition of β-amyloid (Aβ) plaques which is a potential target for the early diagnosis of AD. Positron emission tomography (PET), a sensitive radionuclide imaging technique, has provided opportunities to detect Aβ plaques of AD. PET-imaging probes of Aβ plaques have been extensively developed during the last decade. [18F]Florbetapir, the 18F-labeled PET-imaging probe of Aβ plaques, was recently approved by US Food and Drug Administration. A number of follow-on PET-imaging probes are currently being developed in academia and pharmaceutical companies. This article will discuss the recent development of PET-imaging probes from [11C]PIB to [ 18F]Florbetapir, which are in clinic trials, and several follow-on probes in preclinical stage. © 2013 The Pharmaceutical Society of Korea.
- Pharmaceutical Society of Korea
- Related Researcher
Koo, Jae Hyung
The Koo Lab - ChemoReception Laboratory(CRLab)
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